Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.47 |
| ▸ | TUBB | P07437 | 1/20 | 0.47 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.47 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.47 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.47 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.47 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.47 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.47 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.47 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.47 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.47 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.47 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.47 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.47 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.47 |
| ▸ | MMP1 | P03956 | 5/20 | 0.45 |
| ▸ | MMP2 | P08253 | 5/20 | 0.45 |
| ▸ | MMP9 | P14780 | 5/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6582938 | 1.00 | NPC1 (0.51) | NPC1RAB9ATUBB4ATUBBTUBA3C | |
| SCHEMBL9767884 | 0.82 | TRPM2 (0.60) | NPC1RAB9AHSP90AA1KDM4ERECQL | |
| SCHEMBL13320651 | 0.82 | TRPM2 (0.60) | NPC1RAB9AHSP90AA1KDM4ERECQL | |
| SCHEMBL530137 | 0.81 | MMP1 (0.70) | NPC1RAB9AMMP1MMP2MMP9 | |
| SCHEMBL1959389 | 0.81 | MMP1 (0.70) | NPC1RAB9AMMP1MMP2MMP9 | |
| SCHEMBL13352230 | 0.80 | MMP1 (0.64) | NPC1RAB9ATUBB4ATUBBTUBA3C | |
| SCHEMBL20657312 | 0.80 | HDAC1 (0.47) | NPC1RAB9ATUBB4ATUBBTUBA3C | |
| SCHEMBL10938927 | 0.77 | KDM4E (0.67) | KDM4ERECQLMAPT | |
| SCHEMBL529589 | 0.76 | FABP4 (0.49) | MMP1MMP2MMP9EGFRMAOA | |
| SCHEMBL529588 | 0.76 | FABP4 (0.49) | MMP1MMP2MMP9EGFRMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0846689-B1 | Benzimidazole compounds | PFIZER (US) | 2004-01-14 | — | — | EP | disclosed |
| EP-0846689-A1 | Benzimidazole compounds | PFIZER INC. (US) | 1998-06-10 | — | — | EP | disclosed |