Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 4/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | PDE2A | O00408 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6588623 | 0.96 | FAAH (0.53) | FAAHMEN1MAPTKMT2AHTR1A | |
| SCHEMBL6584608 | 0.87 | FAAH (0.60) | FAAHMEN1MAPTKMT2AGRIN2B | |
| SCHEMBL1331198 | 0.83 | FAAH (0.65) | FAAHMEN1MAPTKMT2AHTR1A | |
| SCHEMBL17289123 | 0.83 | FAAH (0.65) | FAAHMEN1MAPTKMT2AHTR1A | |
| SCHEMBL13940592 | 0.81 | HRH3 (0.58) | FAAHMEN1KMT2AGRIN2BHTR1A | |
| SCHEMBL1332790 | 0.80 | SLC2A1 (0.51) | FAAHMEN1MAPTKMT2AHTR1A | |
| SCHEMBL13150413 | 0.80 | SIGMAR1 (0.59) | FAAHKMT2A | |
| SCHEMBL6769249 | 0.80 | CCR2 (0.58) | FAAHMEN1MAPTKMT2AGRIN2B | |
| SCHEMBL23750987 | 0.79 | FAAH (0.55) | FAAHMEN1MAPTKMT2AHTR1A | |
| SCHEMBL7495658 | 0.79 | FAAH (0.55) | FAAHMEN1MAPTKMT2AHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0957100-B1 | DIAMINE DERIVATIVES AND PHARMACEUTICAL CONTAINING THE SAME | KOWA CO (JP) | 2004-10-27 | — | — | EP | disclosed |
| US-6127360-A | ANTIHISTAMINES, ANTILEUKOTRIENES, ANTIINFLAMMATORY AGENTS, ANTIASTHMATIC AGENTS | KOWA CO., LTD. (JP) | 2000-10-03 | — | — | US | disclosed |
| EP-0957100-A1 | DIAMINE DERIVATIVES AND PHARMACEUTICAL CONTAINING THE SAME | Kowa Co., Ltd. (JP) | 1999-11-17 | — | — | EP | disclosed |