Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 2/20 | 0.48 |
| ▸ | GPR119 | Q8TDV5 | 13/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.44 |
| ▸ | CDK9 | P50750 | 1/20 | 0.44 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.44 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4646351 | 0.90 | KDM4E (0.53) | FAAHACHEGPR119KDM4EPKM | |
| SCHEMBL6582539 | 0.85 | NOS2 (0.44) | FAAHGPR119 | |
| SCHEMBL30000193 | 0.84 | ALDH1A1 (0.56) | ACHEGPR119CCNT1DDB1CRBN | |
| SCHEMBL1748523 | 0.84 | ALDH1A1 (0.56) | ACHEGPR119CCNT1DDB1CRBN | |
| SCHEMBL23088145 | 0.82 | FAAH (0.43) | FAAHACHEGPR119KDM4EPKM | |
| SCHEMBL20618555 | 0.82 | FAAH (0.43) | FAAHACHEGPR119KDM4EPKM | |
| SCHEMBL6585898 | 0.82 | GPR119 (0.48) | GPR119KDM4EPKM | |
| SCHEMBL19461969 | 0.81 | FAAH (0.50) | FAAHGPR119KDM4EPKM | |
| SCHEMBL6584233 | 0.80 | KDM4E (0.51) | FAAHACHEGPR119KDM4EPKM | |
| SCHEMBL2331813 | 0.80 | USP30 (0.50) | ACHEDDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1455788-A1 | 1-GLYCINYL-4-AMINOMETHYL-PIPERIDINE DERIVATIVES AS FACTOR XA INHIBITORS | ELI LILLY AND COMPANY (US) | 2004-09-15 | — | — | EP | disclosed |
| WO-2003049737-A1 | CHEMICAL COMPOUNDS | ELI LILLY AND COMPANY (US) | 2003-06-19 | — | — | WO | disclosed |