Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | AR | P10275 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL628857 | 0.89 | SMN1; SMN2 (0.71) | SMN1; SMN2ALDH1A1MEN1KMT2APOLB | |
| SCHEMBL8017456 | 0.84 | SMN1; SMN2 (0.51) | SMN1; SMN2POLBMAPTNPC1RAB9A | |
| SCHEMBL2117441 | 0.84 | ALOX15 (0.50) | SMN1; SMN2ALDH1A1MEN1KMT2APOLB | |
| SCHEMBL3389094 | 0.83 | SMN1; SMN2 (0.79) | SMN1; SMN2KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL9220908 | 0.83 | SMN1; SMN2 (0.59) | SMN1; SMN2KDM4EMEN1KMT2AHIF1A | |
| SCHEMBL12611856 | 0.81 | ALDH1A1 (0.63) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL12227872 | 0.80 | SMN1; SMN2 (0.54) | SMN1; SMN2KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL197953 | 0.79 | SMN1; SMN2 (0.53) | SMN1; SMN2KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL2717154 | 0.79 | MAPT (0.62) | KDM4EALDH1A1MEN1KMT2AHTT | |
| SCHEMBL2721374 | 0.79 | LMNA (0.56) | SMN1; SMN2KDM4EALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1060175-B1 | TRYPTASE INHIBITORS | MAX PLANCK GESELLSCHAFT (DE) | 2004-11-17 | — | — | EP | disclosed |
| US-6613769-B1 | Incubating samples with enzyme inhibitors, then determining complexes formed; medical diagnosis; therapy for allergies and inflammation | Max-Planck-Gesellschaft zur Föderung der Wissenschaften. e.V. (DE) | 2003-09-02 | — | — | US | disclosed |
| US-6489327-B1 | TREATING A DISEASE SUSCEPTIBLE TO TRYPTASE INHIBITION SUCH AS ASTHMA, INFLAMMATORY BOWEL DISEASE, PSORIASIS OR RHINITIS | MAX-PLANCK-GESELLSCHAFT ZUR FORDRUNGDER WISENSCHAFTEN, E.V. (DE) | 2002-12-03 | — | — | US | disclosed |
| EP-1060171-A2 | TRYPTASE INHIBITORS | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2000-12-20 | — | — | EP | disclosed |
| EP-1060175-A2 | TRYPTASE INHIBITORS | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2000-12-20 | — | — | EP | disclosed |
| WO-1999040083-A2 | BIFUNCTIONAL TRYPTASE INHIBITORS | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 1999-08-12 | — | — | WO | disclosed |
| WO-1999040073-A2 | TRYPTASE INHIBITORS | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 1999-08-12 | — | — | WO | disclosed |