SCHEMBL6584534

SCHEMBL6584534

CC(=O)N1CCC(CN2CCC(N)CC2)CC1

nearest known ligand 0.45

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CXCR3 P49682 1/20 0.45
SMN1; SMN2 Q16637 1/20 0.41
GNAI3 P08754 1/20 0.41
GNAO1 P09471 1/20 0.41
GNAI1 P63096 1/20 0.41
MAPT P10636 1/20 0.39
HTR4 Q13639 2/20 0.39
HTR3A P46098 1/20 0.39
GAA P10253 1/20 0.38
ACHE P22303 1/20 0.38
LMNA P02545 1/20 0.38
EPHX1 P07099 1/20 0.38
EPHX2 P34913 1/20 0.38
THRB P10828 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6585178 0.84 SMN1; SMN2 (0.42) SMN1; SMN2GNAI3GNAO1GNAI1MAPT
SCHEMBL24669825 0.84 CXCR3 (0.46) CXCR3SMN1; SMN2MAPTHTR4HTR3A
SCHEMBL17285913 0.84 ACHE (0.56) CXCR3SMN1; SMN2ACHELMNATHRB
SCHEMBL12506852 0.84 CHRM5 (0.52) CXCR3SMN1; SMN2MAPTGAALMNA
SCHEMBL6586007 0.83 POLB (0.47) MAPTGAALMNATHRB
SCHEMBL90563 0.83 CYP1A2 (0.48) SMN1; SMN2GNAI3GNAO1GNAI1EPHX1
SCHEMBL22878311 0.83 CXCR3 (0.45) CXCR3SMN1; SMN2MAPTHTR4HTR3A
SCHEMBL6586735 0.82 MAPT (0.44) SMN1; SMN2GNAI3GNAO1GNAI1MAPT
SCHEMBL6585893 0.82 HTR4 (0.43) MAPTHTR4HTR3AGAALMNA
SCHEMBL6584309 0.81 SMN1; SMN2 (0.51) SMN1; SMN2MAPTGAALMNATHRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2015177326-A1 5-CHLORO-2-DIFLUOROMETHOXYPHENYL PYRAZOLOPYRIMIDINE COMPOUNDS WHICH ARE JAK INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2015-11-26 WO disclosed
EP-1076055-B1 1- (1-SUBSTITUTED-4-PIPERIDINYL)METHYL]-4-PIPERIDINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, MEDICINAL COMPOSITIONS CONTAINING THE SAME AND INTERMEDIATES OF THESE COMPOUNDS DAINIPPON PHARMACEUTICAL CO (JP) 2004-11-24 EP disclosed
CN-1118452-C 1-[(1-substituted-4-piperidinyl) methyl]-4-piperidine derivatives, process for producing the same medicinal compositions containing the same and intermediate of these compounds DAINIPPON PHARMACEUTICAL CO (JP) 2003-08-20 CN disclosed
US-6294555-B1 SEROTONIN HT3 RECEPTOR ANTAGONIST FOR GASTROINTESTINAL DISORDERS DAINIPPON PHARMACEUTICAL CO., LTD. (JP) 2001-09-25 US disclosed
CN-1298391-A 1-[(1-substituted-4-piperidinyl) methyl]-4-piperidine derivatives, process for producing the same medicinal compositions containing the same and intermediate of these compounds DAINIPPON PHARMACEUTICAL CO (JP) 2001-06-06 CN disclosed
EP-1076055-A1 1- (1-SUBSTITUTED-4-PIPERIDINYL)METHYL]-4-PIPERIDINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, MEDICINAL COMPOSITIONS CONTAINING THE SAME AND INTERMEDIATES OF THESE COMPOUNDS Dainippon Pharmaceutical Co., Ltd. (JP) 2001-02-14 EP disclosed