Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 6/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13208402 | 0.86 | POLB (0.62) | POLBLMNA | |
| SCHEMBL6584534 | 0.83 | CXCR3 (0.45) | MAPTGAATHRBLMNA | |
| SCHEMBL6585893 | 0.83 | HTR4 (0.43) | POLBMAPTGAATHRBLMNA | |
| SCHEMBL6585178 | 0.81 | SMN1; SMN2 (0.42) | MAPTGAATHRBTP53LMNA | |
| SCHEMBL6586735 | 0.79 | MAPT (0.44) | MAPTGAA | |
| SCHEMBL6584309 | 0.79 | SMN1; SMN2 (0.51) | POLBMAPTGAATHRBTP53 | |
| SCHEMBL6587099 | 0.78 | FAAH (0.62) | MAPTGAATHRBTP53LMNA | |
| SCHEMBL14450743 | 0.78 | POLB (0.56) | POLBMAPTLMNA | |
| SCHEMBL6586716 | 0.77 | SMN1; SMN2 (0.54) | MAPTGAATHRBTP53LMNA | |
| SCHEMBL7839825 | 0.77 | HTR1A (0.46) | POLBMAPTTHRBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1076055-B1 | 1- (1-SUBSTITUTED-4-PIPERIDINYL)METHYL]-4-PIPERIDINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, MEDICINAL COMPOSITIONS CONTAINING THE SAME AND INTERMEDIATES OF THESE COMPOUNDS | DAINIPPON PHARMACEUTICAL CO (JP) | 2004-11-24 | — | — | EP | disclosed |
| US-6294555-B1 | SEROTONIN HT3 RECEPTOR ANTAGONIST FOR GASTROINTESTINAL DISORDERS | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 2001-09-25 | — | — | US | disclosed |
| EP-1076055-A1 | 1- (1-SUBSTITUTED-4-PIPERIDINYL)METHYL]-4-PIPERIDINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, MEDICINAL COMPOSITIONS CONTAINING THE SAME AND INTERMEDIATES OF THESE COMPOUNDS | Dainippon Pharmaceutical Co., Ltd. (JP) | 2001-02-14 | — | — | EP | disclosed |