Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 4/20 | 0.43 |
| ▸ | HTR3A | P46098 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL828224 | 0.88 | BRD4 (0.45) | HTR4HTR3AKCNH2CHRM4BRD4 | |
| SCHEMBL1564372 | 0.85 | EPHX1 (0.44) | BRD4GAAMAPTTHRB | |
| Hydrochloric Acid SCHEMBL4097350 | 0.83 | GNAI3 (0.46) | BRD4GAAMAPTTHRB | |
| SCHEMBL6586007 | 0.83 | POLB (0.47) | POLBGAALMNAMAPTTHRB | |
| SCHEMBL6584534 | 0.82 | CXCR3 (0.45) | HTR4HTR3AGAALMNAMAPT | |
| SCHEMBL21280800 | 0.81 | PKM (0.42) | HTR4HTR3AKCNH2BRD4POLB | |
| SCHEMBL6585178 | 0.80 | SMN1; SMN2 (0.42) | GAALMNAMAPTTHRB | |
| SCHEMBL6586631 | 0.80 | GNAI3 (0.47) | HTR4POLB | |
| SCHEMBL19013629 | 0.79 | CACNA2D1 (0.51) | HTR4HTR3ACHRM4BRD4POLB | |
| SCHEMBL18909455 | 0.79 | PKM (0.43) | HTR4CHRM4BRD4POLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1076055-B1 | 1- (1-SUBSTITUTED-4-PIPERIDINYL)METHYL]-4-PIPERIDINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, MEDICINAL COMPOSITIONS CONTAINING THE SAME AND INTERMEDIATES OF THESE COMPOUNDS | DAINIPPON PHARMACEUTICAL CO (JP) | 2004-11-24 | — | — | EP | disclosed |
| CN-1118452-C | 1-[(1-substituted-4-piperidinyl) methyl]-4-piperidine derivatives, process for producing the same medicinal compositions containing the same and intermediate of these compounds | DAINIPPON PHARMACEUTICAL CO (JP) | 2003-08-20 | — | — | CN | disclosed |
| US-6294555-B1 | SEROTONIN HT3 RECEPTOR ANTAGONIST FOR GASTROINTESTINAL DISORDERS | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 2001-09-25 | — | — | US | disclosed |
| CN-1298391-A | 1-[(1-substituted-4-piperidinyl) methyl]-4-piperidine derivatives, process for producing the same medicinal compositions containing the same and intermediate of these compounds | DAINIPPON PHARMACEUTICAL CO (JP) | 2001-06-06 | — | — | CN | disclosed |
| EP-1076055-A1 | 1- (1-SUBSTITUTED-4-PIPERIDINYL)METHYL]-4-PIPERIDINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, MEDICINAL COMPOSITIONS CONTAINING THE SAME AND INTERMEDIATES OF THESE COMPOUNDS | Dainippon Pharmaceutical Co., Ltd. (JP) | 2001-02-14 | — | — | EP | disclosed |