Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | CCR1 | P32246 | 1/20 | 0.37 |
| ▸ | UBE2M | P61081 | 1/20 | 0.37 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.37 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7343066 | 0.85 | UBE2M (0.41) | TRPV1MAPK1DPP4KCNH2DPP7 | |
| SCHEMBL6586315 | 0.72 | DPP4 (0.37) | DPP4KCNH2DPP7CCR1TSHR | |
| SCHEMBL30454028 | 0.70 | MAPK1 (0.64) | MAPK1ALDH1A1KMT2AHTTMAPT | |
| SCHEMBL5857969 | 0.70 | MAPK1 (0.64) | MAPK1ALDH1A1KMT2AHTTMAPT | |
| SCHEMBL6584115 | 0.69 | TRPV1 (0.47) | TRPV1HTTCCR1GAA | |
| SCHEMBL15474535 | 0.66 | MAPK1 (0.43) | TRPV1MAPK1ALDH1A1KMT2AHTT | |
| SCHEMBL15474536 | 0.66 | MAPK1 (0.43) | TRPV1MAPK1ALDH1A1KMT2AHTT | |
| SCHEMBL6584118 | 0.66 | CCR1 (0.46) | DPP4KCNH2DPP7CCR1 | |
| SCHEMBL4910244 | 0.66 | SGMS2 (0.47) | MAPK1ALDH1A1KMT2AHTTSGMS2 | |
| SCHEMBL4910166 | 0.65 | LMNA (0.63) | MAPK1ALDH1A1KMT2AHTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0815080-B1 | DI-SUBSTITUTED 1,4-PIPERIDINE ESTERS AND AMIDES HAVING 5-HT4 ANTAGONISTIC ACTIVITY | BOEHRINGER INGELHEIM ITALIA (IT) | 2004-06-16 | — | — | EP | disclosed |
| US-6002009-A | Di-substituted 1,4-piperidine esters and amides having 5-HT4 antagonistic activity | BOEHRINGER INGELHEIM ITALIA, S.P.A. (IT) | 1999-12-14 | — | — | US | disclosed |