Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 8/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.32 |
| ▸ | SMO | Q99835 | 1/20 | 0.32 |
| ▸ | HTR7 | P34969 | 3/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | AKT1 | P31749 | 1/20 | 0.32 |
| ▸ | RBP4 | P02753 | 1/20 | 0.31 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.30 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6586745 | 0.76 | HTR1A (0.48) | HTR1ASMO | |
| SCHEMBL17865501 | 0.72 | SPHK1 (0.52) | SPHK1DPP4 | |
| SCHEMBL3594485 | 0.72 | SPHK1 (0.52) | SPHK1DPP4 | |
| SCHEMBL6587595 | 0.71 | HTR1A (0.51) | HTR1AHTR7AKT1RBP4 | |
| SCHEMBL6589366 | 0.69 | HTR1A (0.61) | HTR1AAKT1 | |
| SCHEMBL9594541 | 0.68 | SPHK1 (0.47) | SPHK1HTR7DPP4SIRT1 | |
| SCHEMBL7332918 | 0.65 | ATM (0.50) | SPHK1DPP4SIRT1 | |
| SCHEMBL11147860 | 0.64 | SPHK1 (0.52) | SPHK1SIRT1 | |
| SCHEMBL6586359 | 0.64 | HTR1A (0.58) | HTR1ASMOAKT1 | |
| SCHEMBL6068426 | 0.64 | DPP4 (0.42) | DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1161424-B1 | NEW DIAZOLE DERIVATIVES AS SEROTONERGIC AGENTS | WYETH CORP (US) | 2004-06-02 | — | — | EP | claimed |
| US-6239134-B1 | TREATING CENTRAL NERVOUS SYSTEM DISORDERS USING THESE COMPOUNDS. NOVEL DIAZOLEPIPERAZINE, DIAZOLEPIPERIDINE, AND DIAZOLEDIHYDROPIPERIDINE DERIVATIVES, | AMERICAN HOME PRODUCTS CORP. | 2001-05-29 | — | — | US | claimed |