Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 7/20 | 0.58 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.43 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.37 |
| ▸ | SMO | Q99835 | 1/20 | 0.37 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.36 |
| ▸ | HTR3B | O95264 | 2/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | HTR3A | P46098 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL6592709 | 0.92 | HTR1A (0.58) | HTR1ASLC6A4SLC6A3AKT1SLC6A2 | |
| SCHEMBL6589366 | 0.83 | HTR1A (0.61) | HTR1AAKT1DRD4DRD3 | |
| SCHEMBL6586745 | 0.76 | HTR1A (0.48) | HTR1AALDH1A1ALOX15TSHRMAPK1 | |
| SCHEMBL6586750 | 0.76 | SIGMAR1 (0.58) | ALDH1A1KDM4E | |
| SCHEMBL13405022 | 0.76 | DRD4 (0.57) | HTR1ASLC6A4SLC6A3EPHX1ALDH1A1 | |
| SCHEMBL31232789 | 0.76 | DRD4 (0.57) | HTR1ASLC6A4SLC6A3EPHX1ALDH1A1 | |
| SCHEMBL6706541 | 0.75 | SIGMAR1 (0.62) | SLC6A4SLC6A3EPHX1ALDH1A1KDM4E | |
| SCHEMBL6590854 | 0.74 | HTR1A (1.00) | HTR1AMAPK1DRD4DRD3 | |
| SCHEMBL27489107 | 0.74 | HTR1A (1.00) | HTR1AMAPK1DRD4DRD3 | |
| SCHEMBL4555805 | 0.72 | MAPT (0.48) | HTR1AALDH1A1ALOX15TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1161424-B1 | NEW DIAZOLE DERIVATIVES AS SEROTONERGIC AGENTS | WYETH CORP (US) | 2004-06-02 | — | — | EP | claimed |
| US-6239134-B1 | TREATING CENTRAL NERVOUS SYSTEM DISORDERS USING THESE COMPOUNDS. NOVEL DIAZOLEPIPERAZINE, DIAZOLEPIPERIDINE, AND DIAZOLEDIHYDROPIPERIDINE DERIVATIVES, | AMERICAN HOME PRODUCTS CORP. | 2001-05-29 | — | — | US | claimed |