Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | QDPR | P09417 | 3/20 | 0.44 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 7/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.39 |
| ▸ | KHK | P50053 | 2/20 | 0.39 |
| ▸ | FABP4 | P15090 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6584726 | 0.82 | QDPR (0.46) | QDPRCD274HTR2CSIGMAR1BRD4 | |
| SCHEMBL6584948 | 0.78 | SIGMAR1 (0.65) | QDPRHTR2CSIGMAR1KHK | |
| SCHEMBL6587136 | 0.75 | DYRK1A (0.46) | BRD4CREBBPDYRK1AFABP4 | |
| SCHEMBL7804971 | 0.74 | QDPR (0.57) | QDPRCD274HTR2CSIGMAR1PRMT5 | |
| SCHEMBL6586022 | 0.74 | SIGMAR1 (0.52) | QDPRHTR2CSIGMAR1 | |
| SCHEMBL14956908 | 0.74 | QDPR (0.60) | QDPRHTR2CSIGMAR1KHK | |
| SCHEMBL27007773 | 0.73 | QDPR (0.47) | QDPRHTR2CSIGMAR1KHK | |
| SCHEMBL6586935 | 0.73 | QDPR (0.50) | QDPRCD274HTR2CSIGMAR1KHK | |
| SCHEMBL6585457 | 0.72 | HTR2C (0.76) | QDPRHTR2CSIGMAR1 | |
| SCHEMBL27025885 | 0.72 | QDPR (0.48) | QDPRHTR2CSIGMAR1KHK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1036062-B1 | HYDROXAMIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE (MMP) INHIBITORS | PFIZER LTD (GB) | 2004-01-02 | — | — | EP | disclosed |
| US-6495568-B1 | TREATMENT OF TISSUE ULCERATION, WOUND REPAIR AND SKIN DISEASES | WARNER-LAMBERT COMPANY | 2002-12-17 | — | — | US | disclosed |
| EP-1036062-A1 | HYDROXAMIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE (MMP) INHIBITORS | Pfizer Limited (GB) | 2000-09-20 | — | — | EP | disclosed |
| WO-1999029667-A1 | HYDROXAMIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE (MMP) INHIBITORS | PFIZER LIMITED (GB) | 1999-06-17 | — | — | WO | disclosed |