Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | QDPR | P09417 | 3/20 | 0.57 |
| ▸ | HTR2C | P28335 | 8/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.54 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.41 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6043424 | 0.90 | QDPR (0.57) | QDPRHTR2CSIGMAR1 | |
| SCHEMBL6584726 | 0.79 | QDPR (0.46) | QDPRHTR2CSIGMAR1CD274ALOX5 | |
| SCHEMBL5090686 | 0.75 | QDPR (0.48) | QDPRHTR2CSIGMAR1PRMT5WDR77 | |
| SCHEMBL6586461 | 0.74 | CHEK1 (0.44) | QDPRHTR2CSIGMAR1CD274PRMT5 | |
| SCHEMBL15677665 | 0.73 | ALOX5 (0.72) | CD274ALOX5NOTUM | |
| SCHEMBL7744628 | 0.72 | QDPR (1.00) | QDPRHTR2CSIGMAR1 | |
| SCHEMBL31367896 | 0.72 | QDPR (1.00) | QDPRHTR2CSIGMAR1 | |
| SCHEMBL3383939 | 0.72 | HTR2C (0.62) | QDPRHTR2CSIGMAR1 | |
| SCHEMBL14956908 | 0.72 | QDPR (0.60) | QDPRHTR2CSIGMAR1 | |
| SCHEMBL3385014 | 0.72 | SIGMAR1 (0.68) | QDPRHTR2CSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0745598-B1 | Piperazine, piperidine and 1,2,5,6-tetrahydropyridine derivatives, proces for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 2001-08-22 | — | — | EP | disclosed |
| US-5753662-A | TREATING DOPAMINERGIC SYSTEM DISORDERS | ADIR ET COMPAGNIE (FR) | 1998-05-19 | — | — | US | disclosed |
| US-5684020-A | ANTIPSYCHOTICS, ANTIDEPRESSANTS, TREATMENT OF DYSFUNCTION OF DOPAMINERGIC SYSTEM | ADIR ET COMPAGNIE (FR) | 1997-11-04 | — | — | US | disclosed |
| EP-0745598-A1 | Piperazine, piperidine and 1,2,5,6-tetrahydropyridine derivatives, proces for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-12-04 | — | — | EP | disclosed |