Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 9/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6584309 | 0.98 | SMN1; SMN2 (0.51) | SMN1; SMN2CHRM5ADRA2CALDH1A1MAPT | |
| SCHEMBL14275787 | 0.84 | ALDH1A1 (0.61) | SMN1; SMN2ALDH1A1TP53LMNAHSD11B1 | |
| SCHEMBL382920 | 0.82 | ALDH1A1 (0.56) | ALDH1A1TP53HSD11B1 | |
| SCHEMBL6585178 | 0.81 | SMN1; SMN2 (0.42) | SMN1; SMN2CHRM5ADRA2CMAPTTP53 | |
| SCHEMBL6584534 | 0.80 | CXCR3 (0.45) | SMN1; SMN2MAPTTHRBLMNAACHE | |
| SCHEMBL6586007 | 0.77 | POLB (0.47) | MAPTTP53THRBLMNAGAA | |
| SCHEMBL6589869 | 0.77 | CHRM5 (0.67) | SMN1; SMN2CHRM5ADRA2CACHE | |
| SCHEMBL1586529 | 0.77 | CHRM5 (0.67) | SMN1; SMN2CHRM5ADRA2CACHE | |
| SCHEMBL11545422 | 0.77 | CHRM5 (0.67) | SMN1; SMN2CHRM5ADRA2CACHE | |
| SCHEMBL1136825 | 0.76 | GNAI3 (0.46) | ALDH1A1TP53HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1076055-B1 | 1- (1-SUBSTITUTED-4-PIPERIDINYL)METHYL]-4-PIPERIDINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, MEDICINAL COMPOSITIONS CONTAINING THE SAME AND INTERMEDIATES OF THESE COMPOUNDS | DAINIPPON PHARMACEUTICAL CO (JP) | 2004-11-24 | — | — | EP | disclosed |
| US-6294555-B1 | SEROTONIN HT3 RECEPTOR ANTAGONIST FOR GASTROINTESTINAL DISORDERS | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 2001-09-25 | — | — | US | disclosed |
| EP-1076055-A1 | 1- (1-SUBSTITUTED-4-PIPERIDINYL)METHYL]-4-PIPERIDINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, MEDICINAL COMPOSITIONS CONTAINING THE SAME AND INTERMEDIATES OF THESE COMPOUNDS | Dainippon Pharmaceutical Co., Ltd. (JP) | 2001-02-14 | — | — | EP | disclosed |