Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K7 | O43318 | 16/20 | 0.48 |
| ▸ | TAB1 | Q15750 | 16/20 | 0.48 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL658922 | 0.83 | MAP3K7 (0.53) | MAP3K7TAB1KDRAURKBBRAF | |
| SCHEMBL659026 | 0.75 | RAB9A (0.58) | MAP3K7TAB1NPC1RAB9ATLR8 | |
| SCHEMBL664646 | 0.73 | MAP3K7 (0.64) | MAP3K7TAB1KDRAURKBTLR8 | |
| SCHEMBL10219502 | 0.71 | MAP3K7 (0.57) | MAP3K7TAB1KDRAURKB | |
| SCHEMBL660235 | 0.70 | LMNA (0.44) | MAP3K7TAB1RAB9ATLR8 | |
| SCHEMBL5620698 | 0.69 | ALDH1A1 (0.46) | MAP3K7TAB1KDRAURKBBRAF | |
| SCHEMBL659267 | 0.65 | MAP3K7 (0.49) | MAP3K7TAB1KDRAURKBTLR8 | |
| SCHEMBL659236 | 0.65 | TLR8 (0.40) | MAP3K7TAB1KDRAURKBTLR8 | |
| SCHEMBL659979 | 0.65 | TLR8 (0.40) | MAP3K7TAB1KDRAURKBTLR8 | |
| SCHEMBL657642 | 0.64 | BRAF (0.42) | MAP3K7TAB1KDRAURKBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8378104-B2 | 7-aminofuropyridine derivatives | OSI Pharmaceuticals, LLC (US) | 2013-02-19 | — | — | US | disclosed |
| US-20120046267-A1 | 7-AMINOFUROPYRIDINE DERIVATIVES | OSI PHARMACEUTICALS, INC. | 2012-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046267-A1 | 7-AMINOFUROPYRIDINE DERIVATIVES | MAP3K5, STK17A, MAPKAPK5 | MAP3K7 5/4885TAB1 4/4885KDR 3584/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.