Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 2/20 | 0.48 |
| ▸ | MMP9 | P14780 | 2/20 | 0.48 |
| ▸ | MMP1 | P03956 | 1/20 | 0.48 |
| ▸ | MMP2 | P08253 | 1/20 | 0.48 |
| ▸ | MMP3 | P08254 | 1/20 | 0.48 |
| ▸ | MMP7 | P09237 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 3/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.47 |
| ▸ | CA7 | P43166 | 2/20 | 0.47 |
| ▸ | CA9 | Q16790 | 2/20 | 0.47 |
| ▸ | JMJD7 | P0C870 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6769979 | 1.00 | MMP13 (0.48) | MMP13MMP9MMP1MMP2MMP3 | |
| SCHEMBL6774113 | 0.82 | CA12 (0.51) | MMP13MMP9MMP1MMP2MMP3 | |
| SCHEMBL6588744 | 0.82 | CA12 (0.51) | MMP13MMP9MMP1MMP2MMP3 | |
| SCHEMBL2995728 | 0.80 | MAPT (0.48) | MMP13MMP9MMP1MMP2MMP3 | |
| SCHEMBL3617858 | 0.79 | MMP2 (0.77) | MMP13MMP9MMP1MMP2MMP3 | |
| SCHEMBL3103313 | 0.79 | MMP2 (0.77) | MMP13MMP9MMP1MMP2MMP3 | |
| SCHEMBL11722467 | 0.76 | GAA (0.54) | CA12CA7CA9JMJD7GAA | |
| SCHEMBL14551893 | 0.74 | SSTR3 (0.50) | CA12CA9GAAMAPTKMT2A | |
| SCHEMBL6588625 | 0.74 | ADAMTS4 (0.53) | MMP13MMP9MMP1MMP2CA12 | |
| SCHEMBL9303069 | 0.73 | POLB (0.48) | GAAMAPTPOLBKMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1169338-B1 | LOW-MOLECULAR INHIBITORS OF COMPLEMENT PROTEASES | ABBOTT GMBH & CO KG (DE) | 2004-11-03 | — | — | EP | disclosed |
| US-6683055-B1 | GUANIDINE OR AMIDINE TERMINED PEPTIDES | BASF AKTIENGESELLSCHAFT (DE) | 2004-01-27 | — | — | US | disclosed |
| EP-1169338-A2 | LOW-MOLECULAR INHIBITORS OF COMPLEMENT PROTEASES | BASF AKTIENGESELLSCHAFT (DE) | 2002-01-09 | — | — | EP | disclosed |
| WO-2000061608-A2 | LOW-MOLECULAR INHIBITORS OF COMPLEMENT PROTEASES | BASF AKTIENGESELLSCHAFT (DE) | 2000-10-19 | — | — | WO | disclosed |