Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | AKT1 | P31749 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MMP1 | P03956 | 3/20 | 0.45 |
| ▸ | MMP3 | P08254 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | METAP1 | P53582 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6586642 | 0.89 | HTR1A (0.55) | HTR1AKMT2AMEN1SMN1; SMN2KDM4E | |
| SCHEMBL20593920 | 0.75 | MMP1 (0.61) | KMT2AMEN1SMN1; SMN2ALDH1A1MMP1 | |
| SCHEMBL20593922 | 0.75 | MMP1 (0.61) | KMT2AMEN1SMN1; SMN2ALDH1A1MMP1 | |
| SCHEMBL27146672 | 0.75 | HSD17B10 (0.66) | KMT2AMEN1SMN1; SMN2HSD17B10ALDH1A1 | |
| SCHEMBL27146671 | 0.75 | HSD17B10 (0.66) | KMT2AMEN1SMN1; SMN2HSD17B10ALDH1A1 | |
| SCHEMBL6587595 | 0.75 | HTR1A (0.51) | HTR1AKMT2AMEN1SMN1; SMN2HSD17B10 | |
| SCHEMBL27488200 | 0.74 | POLB (0.71) | KMT2AMEN1SMN1; SMN2KDM4EPOLB | |
| SCHEMBL27489107 | 0.73 | HTR1A (1.00) | HTR1A | |
| SCHEMBL6590854 | 0.73 | HTR1A (1.00) | HTR1A | |
| SCHEMBL27146724 | 0.73 | KMT2A (0.54) | KMT2AMEN1SMN1; SMN2ALDH1A1MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1161424-B1 | NEW DIAZOLE DERIVATIVES AS SEROTONERGIC AGENTS | WYETH CORP (US) | 2004-06-02 | — | — | EP | disclosed |
| EP-1161424-A1 | NEW DIAZOLE DERIVATIVES AS SEROTONERGIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-12-12 | — | — | EP | disclosed |
| US-6239134-B1 | TREATING CENTRAL NERVOUS SYSTEM DISORDERS USING THESE COMPOUNDS. NOVEL DIAZOLEPIPERAZINE, DIAZOLEPIPERIDINE, AND DIAZOLEDIHYDROPIPERIDINE DERIVATIVES, | AMERICAN HOME PRODUCTS CORP. | 2001-05-29 | — | — | US | disclosed |
| WO-2000051999-A1 | NEW DIAZOLE DERIVATIVES AS SEROTONERGIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-09-08 | — | — | WO | disclosed |