Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | AKT1 | P31749 | 2/20 | 0.45 |
| ▸ | HRH2 | P25021 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | METAP1 | P53582 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | AKT2 | P31751 | 1/20 | 0.41 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6589346 | 0.89 | HTR1A (0.58) | HTR1AKMT2AMEN1AKT1SMN1; SMN2 | |
| SCHEMBL2829342 | 0.76 | AKT1 (0.72) | AKT1AKT2AKT3 | |
| SCHEMBL2797368 | 0.76 | AKT1 (0.72) | AKT1AKT2AKT3 | |
| SCHEMBL6587595 | 0.75 | HTR1A (0.51) | HTR1AKMT2AMEN1AKT1SMN1; SMN2 | |
| SCHEMBL16254311 | 0.75 | FPR2 (0.59) | KMT2AHRH2HRH1SMN1; SMN2HSD17B10 | |
| SCHEMBL20176845 | 0.73 | MMP8 (0.62) | KMT2AMEN1HRH2HRH1SMN1; SMN2 | |
| SCHEMBL16254296 | 0.73 | MMP8 (0.62) | KMT2AMEN1HRH2HRH1SMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL11220299 | 0.71 | HSD17B10 (0.60) | KMT2AHRH2HRH1SMN1; SMN2HSD17B10 | |
| SCHEMBL6590854 | 0.71 | HTR1A (1.00) | HTR1A | |
| SCHEMBL27489107 | 0.71 | HTR1A (1.00) | HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1161424-B1 | NEW DIAZOLE DERIVATIVES AS SEROTONERGIC AGENTS | WYETH CORP (US) | 2004-06-02 | — | — | EP | disclosed |
| EP-1161424-A1 | NEW DIAZOLE DERIVATIVES AS SEROTONERGIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-12-12 | — | — | EP | disclosed |
| US-6239134-B1 | TREATING CENTRAL NERVOUS SYSTEM DISORDERS USING THESE COMPOUNDS. NOVEL DIAZOLEPIPERAZINE, DIAZOLEPIPERIDINE, AND DIAZOLEDIHYDROPIPERIDINE DERIVATIVES, | AMERICAN HOME PRODUCTS CORP. | 2001-05-29 | — | — | US | disclosed |
| WO-2000051999-A1 | NEW DIAZOLE DERIVATIVES AS SEROTONERGIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-09-08 | — | — | WO | disclosed |