SCHEMBL6589381

SCHEMBL6589381

C=C(C)n1c(Cl)nc2ccccc21

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 4/20 0.56
LMNA P02545 5/20 0.42
TSHR P16473 3/20 0.42
HSD17B10 Q99714 1/20 0.42
KMT2A Q03164 4/20 0.41
ALDH1A1 P00352 1/20 0.41
MEN1 O00255 3/20 0.39
NPC1 O15118 3/20 0.39
RAB9A P51151 3/20 0.39
KDM4E B2RXH2 2/20 0.39
L3MBTL1 Q9Y468 2/20 0.39
CYP1A2 P05177 1/20 0.38
CYP3A4 P08684 1/20 0.38
CYP2D6 P10635 1/20 0.38
MAPK1 P28482 1/20 0.38
PKM P14618 1/20 0.38
GAA P10253 1/20 0.38
TNF P01375 1/20 0.38
NOD2 Q9HC29 1/20 0.38
NOD1 Q9Y239 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28820818 0.80 ALDH1A1 (0.58) SMN1; SMN2LMNATSHRHSD17B10KMT2A
SCHEMBL14495652 0.80 TSHR (0.43) SMN1; SMN2LMNATSHRHSD17B10KMT2A
SCHEMBL28504376 0.79 NPC1 (0.57) SMN1; SMN2LMNAKMT2AMEN1NPC1
SCHEMBL6733842 0.76 SMN1; SMN2 (0.53) SMN1; SMN2LMNATSHRHSD17B10KMT2A
SCHEMBL7394357 0.75 SMN1; SMN2 (0.52) SMN1; SMN2LMNATSHRKMT2AALDH1A1
SCHEMBL28622689 0.75 KDM4E (0.44) SMN1; SMN2LMNATSHRHSD17B10KMT2A
SCHEMBL28820650 0.75 POLB (0.42) SMN1; SMN2LMNATSHRHSD17B10KMT2A
SCHEMBL1053419 0.72 SMN1; SMN2 (1.00) SMN1; SMN2LMNATSHRKMT2AALDH1A1
SCHEMBL66294 0.72 SMN1; SMN2 (0.63) SMN1; SMN2LMNAKMT2AMEN1NPC1
SCHEMBL4698252 0.71 SMN1; SMN2 (0.47) SMN1; SMN2LMNATSHRKMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6815455-B1 ANTIFOAM AGENTS OF MACROPHAGES; PREVENTING ARTERIOSCLEROSIS FUJI PHOTO FILM CO., LTD. (JP) 2004-11-09 US disclosed
US-6787561-B1 HYPERLIPIDEMIA, ARTERIOSCLEROSIS; ORAL ADMINISTRATION; SUPPRESSING THE FORMING OF MACROPHAGES FUJI PHOTO FILM CO., LTD. (JP) 2004-09-07 US disclosed
EP-1197493-B1 BENZIMIDAZOLE COMPOUNDS FUJI PHOTO FILM CO LTD (JP) 2004-03-24 EP disclosed
EP-1197487-B1 BENZIMIDAZOLE COMPOUNDS AND DRUGS CONTAINING THE SAME FUJI PHOTO FILM CO LTD (JP) 2004-01-14 EP disclosed
EP-1197493-A1 BENZIMIDAZOLE COMPOUNDS FUJI PHOTO FILM CO., LTD. (JP) 2002-04-17 EP disclosed
EP-1197487-A1 BENZIMIDAZOLE COMPOUNDS AND DRUGS CONTAINING THE SAME Fuji Photo Film Co., Ltd. (JP) 2002-04-17 EP disclosed