Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28820818 | 0.81 | ALDH1A1 (0.58) | TSHRLMNAHSD17B10KMT2AALDH1A1 | |
| SCHEMBL6589381 | 0.80 | SMN1; SMN2 (0.56) | TSHRLMNAHSD17B10KMT2AALDH1A1 | |
| SCHEMBL28504376 | 0.80 | NPC1 (0.57) | LMNAKMT2ASMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL12831779 | 0.78 | KMT2A (0.38) | TSHRLMNAHSD17B10KMT2AALDH1A1 | |
| SCHEMBL28622689 | 0.76 | KDM4E (0.44) | TSHRLMNAHSD17B10KMT2AALDH1A1 | |
| SCHEMBL28820650 | 0.76 | POLB (0.42) | TSHRLMNAHSD17B10KMT2AALDH1A1 | |
| SCHEMBL179064 | 0.72 | SMN1; SMN2 (0.61) | TSHRLMNAHSD17B10KMT2AALDH1A1 | |
| SCHEMBL4314000 | 0.70 | LMNA (0.50) | LMNAKMT2AALDH1A1SMN1; SMN2CYP1A2 | |
| SCHEMBL6586108 | 0.69 | MEN1 (0.42) | TSHRLMNAHSD17B10KMT2AALDH1A1 | |
| Bromide SCHEMBL11628983 | 0.68 | LMNA (0.49) | LMNAKMT2AALDH1A1SMN1; SMN2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007064553-A2 | THIAZOLE DERIVATIVES AS CXCR3 RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2007-06-07 | — | — | WO | disclosed |