Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | EED | O75530 | 1/20 | 0.32 |
| ▸ | KDM5A | P29375 | 1/20 | 0.30 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.30 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6589723 | 0.83 | RXFP1 (0.31) | RXFP1EED | |
| SCHEMBL8432079 | 0.83 | RXFP1 (0.36) | LMNARXFP1EED | |
| SCHEMBL6593270 | 0.83 | RXFP1 (0.36) | LMNARXFP1EED | |
| SCHEMBL6590388 | 0.81 | SLC6A2 (0.31) | — | |
| SCHEMBL6587765 | 0.71 | LMNA (0.34) | LMNABLMRXFP1EEDCYP2C9 | |
| SCHEMBL6589626 | 0.68 | RXFP1 (0.50) | LMNARXFP1EEDCYP2D6TSHR | |
| SCHEMBL8432083 | 0.68 | RXFP1 (0.35) | LMNABLMRXFP1EEDCYP2C9 | |
| SCHEMBL6593566 | 0.67 | RXFP1 (0.37) | LMNARXFP1EEDCYP2C9ALDH1A1 | |
| SCHEMBL6592827 | 0.67 | ALDH1A1 (0.33) | EEDCYP2C9ALDH1A1CYP2D6TSHR | |
| SCHEMBL6589528 | 0.65 | MMP9 (0.32) | EEDCYP2C9ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0703232-B1 | 2,3-Dihydro-1H-isoindole derivates, a process for their preparation and their use as serotonin reuptake inhibitors | AVENTIS PHARMA INC (US) | 2004-06-30 | — | — | EP | claimed |