⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7665388 | 0.70 | NOS2 (0.31) | — | |
| SCHEMBL3978855 | 0.65 | NOS2 (0.39) | — | |
| SCHEMBL3983126 | 0.64 | MEN1 (0.37) | — | |
| SCHEMBL3977832 | 0.63 | NOS2 (0.37) | — | |
| SCHEMBL25280113 | 0.60 | MEN1 (0.35) | — | |
| SCHEMBL8754575 | 0.58 | SIGMAR1 (0.39) | — | |
| SCHEMBL26353640 | 0.58 | SIGMAR1 (0.34) | — | |
| SCHEMBL25633609 | 0.57 | SIGMAR1 (0.38) | — | |
| SCHEMBL26353562 | 0.57 | SIGMAR1 (0.38) | — | |
| SCHEMBL26353853 | 0.57 | SIGMAR1 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183252-B1 | PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRAZENECA AB (SE) | 2004-02-18 | — | — | EP | disclosed |
| US-6492406-B1 | PROTEIN KINASE C INHIBITORS; ANTIINFLAMMATORY AND IMMUNO-SUPPRESSIVE AGENTS | ASTRAZENECA AB (SE) | 2002-12-10 | — | — | US | disclosed |
| EP-1183252-A1 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | AstraZeneca AB (SE) | 2002-03-06 | — | — | EP | disclosed |
| WO-2000071537-A1 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRAZENECA AB (SE) | 2000-11-30 | — | — | WO | disclosed |