Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.30 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.30 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.30 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.30 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.30 |
| ▸ | APP | P05067 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6589871 | 0.91 | GABRG2 (0.42) | GABRG2GABRB3GABRA5ELANETRPV3 | |
| SCHEMBL20168569 | 0.73 | NR1H2 (0.46) | ELANE | |
| SCHEMBL6591084 | 0.73 | TRPV3 (0.32) | GABRG2GABRB3GABRA5TRPV3 | |
| SCHEMBL6593265 | 0.72 | — | — | |
| SCHEMBL6590950 | 0.70 | — | — | |
| SCHEMBL17286544 | 0.63 | ELANE (0.57) | ELANEAPP | |
| SCHEMBL14765171 | 0.61 | NR1H2 (0.39) | GABRG2GABRB3GABRA5TRPV3CHRM2 | |
| SCHEMBL10064601 | 0.61 | GABRG2 (0.72) | GABRG2GABRB3GABRA5CHRM2CHRM4 | |
| SCHEMBL17355754 | 0.61 | ELANE (0.54) | ELANEAPP | |
| SCHEMBL23723352 | 0.60 | CDK1 (0.47) | GABRG2GABRB3GABRA5CHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358180-B1 | NAPHTHOSTYRIL DERIVATIVES AND THEIR USE AS INHIBITORS OF CYCLIN-DEPENDENT KINASES | HOFFMANN LA ROCHE (CH) | 2004-12-01 | — | — | EP | claimed |