SCHEMBL6590403

SCHEMBL6590403

CC(C)C[CH]C(=O)NC1CCCNC[C@@H]1O

nearest known ligand 0.35

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
TAS1R3 Q7RTX0 1/20 0.35
TAS1R1 Q7RTX1 1/20 0.35
CPN1 P15169 2/20 0.33
CPB2 Q96IY4 2/20 0.33
SLC6A1 P30531 2/20 0.33
SLC6A11 P48066 1/20 0.33
TSHR P16473 1/20 0.33
LMNA P02545 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
SLC6A13 Q9NSD5 1/20 0.33
KDM4E B2RXH2 1/20 0.32
MAPT P10636 1/20 0.32
KMT2A Q03164 1/20 0.32
ATM Q13315 1/20 0.32
CYP2D6 P10635 1/20 0.32
ALOX15 P16050 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5099315 0.74 ARG1 (0.43) CPN1CPB2SLC6A1SLC6A11TSHR
SCHEMBL6206696 0.73 KDM4E (0.34) KDM4EMAPTKMT2AATMCYP2D6
SCHEMBL7421894 0.71 CPN1 (0.32) CPN1CPB2SLC6A1SLC6A11TSHR
SCHEMBL3956512 0.71 CTSK (0.40) SMN1; SMN2ALOX15
SCHEMBL3956504 0.71 CTSK (0.40) SMN1; SMN2ALOX15
SCHEMBL6592080 0.70 PSEN1 (0.37) CPN1CPB2SLC6A1SLC6A11TSHR
SCHEMBL21361034 0.70 SLC6A1 (0.35) CPN1CPB2SLC6A1SLC6A11TSHR
Tert-Butyl Formate SCHEMBL27565564 0.69 CCR2 (0.32) ALOX15
SCHEMBL9287695 0.68 EPHX1 (0.33) SLC6A1SLC6A11TSHRLMNASMN1; SMN2
SCHEMBL6273909 0.68 TAS1R3 (0.32) TAS1R3TAS1R1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1351930-A4 PROTEASE INHIBITORS SMITHKLINE BEECHAM CORP (US) 2004-09-15 EP disclosed
EP-1351930-A2 PROTEASE INHIBITORS SmithKline Beecham Corporation (US) 2003-10-15 EP disclosed
EP-1158986-A4 PROTEASE INHIBITORS SMITHKLINE BEECHAM CORP (US) 2002-03-27 EP disclosed
EP-1158986-A1 PROTEASE INHIBITORS SmithKline Beecham Corporation (US) 2001-12-05 EP disclosed
WO-2001034566-A2 PROTEASE INHIBITORS SMITHKLINE BEECHAM CORPORATION (US) 2001-05-17 WO disclosed
WO-2000038687-A1 PROTEASE INHIBITORS SMITHKLINE BEECHAM CORPORATION (US) 2000-07-06 WO disclosed