Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.72 |
| ▸ | DRD4 | P21917 | 1/20 | 0.72 |
| ▸ | DRD3 | P35462 | 1/20 | 0.72 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | C3AR1 | Q16581 | 2/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6177540 | 0.79 | MEN1 (0.46) | HTR1ADRD4DRD3NPSR1ALDH1A1 | |
| SCHEMBL6586789 | 0.76 | HTR1A (0.61) | HTR1ADRD4DRD3HSD17B10ALDH1A1 | |
| SCHEMBL6588617 | 0.73 | HTR1A (0.61) | HTR1ADRD4DRD3NPSR1LMNA | |
| SCHEMBL6586733 | 0.73 | HTR1A (0.61) | HTR1ADRD4DRD3NPSR1LMNA | |
| SCHEMBL6181828 | 0.69 | MEN1 (0.45) | HTR1ADRD4NPSR1ALDH1A1MAPT | |
| SCHEMBL6176194 | 0.69 | MEN1 (0.52) | HTR1ADRD4NPSR1ALDH1A1GAA | |
| SCHEMBL6588614 | 0.69 | HTR1A (0.66) | HTR1ADRD4DRD3NPSR1LMNA | |
| SCHEMBL6586728 | 0.69 | HTR1A (0.66) | HTR1ADRD4DRD3NPSR1LMNA | |
| SCHEMBL28746727 | 0.67 | KMT2A (0.49) | HTR1ADRD4DRD3LMNAHSD17B10 | |
| SCHEMBL7968949 | 0.66 | MEN1 (0.45) | HTR1ADRD4DRD3POLBC3AR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1161424-B1 | NEW DIAZOLE DERIVATIVES AS SEROTONERGIC AGENTS | WYETH CORP (US) | 2004-06-02 | — | — | EP | claimed |