Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.61 |
| ▸ | DRD4 | P21917 | 1/20 | 0.55 |
| ▸ | DRD3 | P35462 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | SMO | Q99835 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6588617 | 1.00 | HTR1A (0.61) | HTR1ADRD4DRD3ALDH1A1HSD17B10 | |
| SCHEMBL6588614 | 0.80 | HTR1A (0.66) | HTR1ADRD4DRD3ALDH1A1HSD17B10 | |
| SCHEMBL6586728 | 0.80 | HTR1A (0.66) | HTR1ADRD4DRD3ALDH1A1HSD17B10 | |
| SCHEMBL6588749 | 0.76 | HTR1A (1.00) | HTR1ADRD4DRD3ALDH1A1HSD17B10 | |
| SCHEMBL6586789 | 0.74 | HTR1A (0.61) | HTR1ADRD4DRD3ALDH1A1HSD17B10 | |
| SCHEMBL6592525 | 0.73 | HTR1A (0.72) | HTR1ADRD4DRD3ALDH1A1HSD17B10 | |
| SCHEMBL6589548 | 0.73 | HTR1A (0.74) | HTR1ADRD4DRD3ALDH1A1HSD17B10 | |
| SCHEMBL9769074 | 0.73 | LTA4H (0.49) | TSHRKMT2A | |
| SCHEMBL6589369 | 0.72 | HTR1A (0.72) | HTR1ADRD4DRD3ALDH1A1HSD17B10 | |
| SCHEMBL19258136 | 0.69 | SIGMAR1 (0.46) | ALDH1A1HSD17B10KMT2AMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1161424-B1 | NEW DIAZOLE DERIVATIVES AS SEROTONERGIC AGENTS | WYETH CORP (US) | 2004-06-02 | — | — | EP | claimed |
| US-6239134-B1 | TREATING CENTRAL NERVOUS SYSTEM DISORDERS USING THESE COMPOUNDS. NOVEL DIAZOLEPIPERAZINE, DIAZOLEPIPERIDINE, AND DIAZOLEDIHYDROPIPERIDINE DERIVATIVES, | AMERICAN HOME PRODUCTS CORP. | 2001-05-29 | — | — | US | claimed |
| US-6239134-B1 | TREATING CENTRAL NERVOUS SYSTEM DISORDERS USING THESE COMPOUNDS. NOVEL DIAZOLEPIPERAZINE, DIAZOLEPIPERIDINE, AND DIAZOLEDIHYDROPIPERIDINE DERIVATIVES, | AMERICAN HOME PRODUCTS CORP. | 2001-05-29 | — | — | US | disclosed |