Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 6/20 | 0.66 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.48 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28003901 | 0.87 | AHR (0.63) | AHRMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL9300229 | 0.87 | AHR (0.59) | AHRMEN1KMT2AHPGDCYP1A2 | |
| SCHEMBL8685679 | 0.87 | AHR (0.59) | AHRMEN1KMT2AHPGDCYP1A2 | |
| SCHEMBL28239180 | 0.86 | AHR (0.52) | AHRMEN1KMT2AHPGDMAPT | |
| SCHEMBL28863000 | 0.85 | AHR (0.54) | AHRMEN1KMT2AHPGDCYP1A2 | |
| SCHEMBL27364002 | 0.85 | AHR (0.49) | AHRMEN1KMT2AHPGDCYP1A2 | |
| SCHEMBL28735487 | 0.85 | AHR (0.49) | AHRMEN1KMT2AHPGDCYP1A2 | |
| SCHEMBL28490003 | 0.83 | MAOA (0.51) | AHRMEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL8804361 | 0.82 | KMT2A (0.48) | AHRMEN1KMT2AHPGDCYP1A2 | |
| SCHEMBL4323256 | 0.82 | GSK3B (0.51) | AHRMEN1KMT2AIMPDH2CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110330535-B | N-heterocyclic carbene-based mixed nickel (II) complex and application thereof | 苏州大学 | 2022-04-15 | — | — | CN | disclosed |
| CN-110330535-B | N-heterocyclic carbene-based mixed nickel (II) complex and application thereof | 苏州大学 | 2022-04-15 | — | — | CN | disclosed |
| CN-110330535-A | N-heterocyclic carbine base mixed matching nickel (II) complex and its application | 苏州大学 | 2019-10-15 | — | — | CN | disclosed |
| CN-108358923-A | Sophoridine pyrroles, indole derivatives and the preparation method and application thereof | 广西大学 | 2018-08-03 | — | — | CN | disclosed |
| CN-108047226-A | Matrine pyrroles, indole derivatives and preparation method and application | 广西大学 | 2018-05-18 | — | — | CN | disclosed |
| CN-103172577-B | 4-amido quinazoline and 4-aminoquinoline compounds and uses thereof | SHENYANG PHARMACEUTICAL UNIVERSITY (CN) | 2015-10-07 | — | — | CN | disclosed |
| CN-102643272-B | Novel thieno [3, 2-d] pyrimidine compound | UNIV SHENYANG PHARMACEUTICAL | 2015-03-11 | — | — | CN | disclosed |
| CN-103172577-A | 4-aminoquinoline and 4-aminoquinoline compound and applications of compound | UNIV SHENYANG PHARMACEUTICAL | 2013-06-26 | — | — | CN | disclosed |
| EP-1359915-A4 | UROTENSIN-II RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM (US) | 2004-07-21 | — | — | EP | disclosed |
| EP-1351687-A4 | UROTENSIN-II RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2004-01-21 | — | — | EP | disclosed |
| EP-1359915-A1 | UROTENSIN-II RECEPTOR ANTAGONISTS | Smithkline Beecham (US) | 2003-11-12 | — | — | EP | disclosed |
| EP-1351687-A2 | UROTENSIN-II RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-10-15 | — | — | EP | disclosed |
| WO-2002058702-A1 | UROTENSIN-II RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (GB) | 2002-08-01 | — | — | WO | disclosed |
| WO-2002047456-A2 | UROTENSIN-II RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-06-20 | — | — | WO | disclosed |
| EP-0837870-A1 | SYNTHETIC MODIFICATION TO SPINOSYN COMPOUNDS | DOWELANCO (US) | 1998-04-29 | — | — | EP | disclosed |
| WO-1997000265-A1 | SYNTHETIC MODIFICATION TO SPINOSYN COMPOUNDS | DOWELANCO (US) | 1997-01-03 | — | — | WO | disclosed |
| EP-0375133-A1 | Alpha-amino-indole-3-acetic acids useful as anti-diabetic, anti-obesity and anti-atherosclerotic agents | THE UPJOHN COMPANY (US) | 1990-06-27 | — | — | EP | disclosed |