Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 3/20 | 0.42 |
| ▸ | ACHE | P22303 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 2/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.39 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22832109 | 0.85 | ALDH1A1 (0.47) | KMT2AALDH1A1NPSR1ACHEMEN1 | |
| SCHEMBL6597445 | 0.85 | RAB9A (0.61) | RAB9AKMT2AGAAALDH1A1PKM | |
| SCHEMBL27352956 | 0.82 | HDAC3 (0.39) | RAB9A | |
| SCHEMBL17553442 | 0.81 | RIPK1 (0.47) | — | |
| SCHEMBL6386036 | 0.81 | CYP3A4 (0.44) | RAB9AGAAALDH1A1 | |
| SCHEMBL2061999 | 0.80 | AKT1 (0.50) | RAB9AKMT2ATSHRMEN1 | |
| SCHEMBL6592346 | 0.80 | NCEH1 (0.41) | ALDH1A1TSHRNCEH1 | |
| SCHEMBL8520811 | 0.79 | RAB9A (0.46) | RAB9AKMT2AGAAALDH1A1PKM | |
| SCHEMBL22649426 | 0.79 | ALOX5 (0.56) | — | |
| SCHEMBL5018764 | 0.78 | LSS (0.44) | KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244663-B1 | COMPOUNDS AND METHODS FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2004-08-25 | — | — | EP | disclosed |
| EP-1244663-A1 | COMPOUNDS AND METHODS FOR THE TREATMENT OF PAIN | AstraZeneca AB (SE) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001047923-A1 | COMPOUNDS AND METHODS FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2001-07-05 | — | — | WO | disclosed |