SCHEMBL6594556

SCHEMBL6594556

Cc1c(-c2cc3cc(OCc4ccccc4Cl)ccc3o2)oc(=O)c(C)c1O

nearest known ligand 0.51

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
SLC26A4 O43511 3/20 0.51
MEN1 O00255 1/20 0.51
KMT2A Q03164 1/20 0.51
TDP1 Q9NUW8 1/20 0.45
ACHE P22303 3/20 0.44
AR P10275 1/20 0.42
MAOB P27338 7/20 0.41
MAOA P21397 2/20 0.41
NR4A2 P43354 2/20 0.39
NPC1 O15118 1/20 0.39
RAB9A P51151 1/20 0.39
POLB P06746 1/20 0.39
PRKDC P78527 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6590051 0.92 TDP1 (0.47) SLC26A4MEN1KMT2ATDP1ACHE
SCHEMBL6592595 0.89 SLC26A4 (0.43) SLC26A4MEN1KMT2AACHEMAOB
SCHEMBL6594593 0.89 SLC26A4 (0.52) SLC26A4MEN1KMT2AACHEMAOB
SCHEMBL6593895 0.89 TDP1 (0.43) SLC26A4MEN1KMT2ATDP1ACHE
SCHEMBL6597833 0.88 MAOB (0.48) SLC26A4MEN1KMT2AACHEAR
SCHEMBL6593972 0.88 ACHE (0.44) SLC26A4ACHEARMAOB
SCHEMBL6595329 0.87 TDP1 (0.47) SLC26A4MEN1KMT2ATDP1ACHE
SCHEMBL6591398 0.86 MAOB (0.54) MEN1KMT2AACHEMAOBMAOA
SCHEMBL6592908 0.86 MAOB (0.43) SLC26A4ACHEARMAOBMAOA
SCHEMBL6597174 0.85 MAOB (0.46) SLC26A4MEN1KMT2AACHEMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1063235-B1 BENZOFURYLPYRONE DERIVATIVES TEIJIN LTD (JP) 2004-05-12 EP disclosed
US-20030186976-A1 Benzofurylpyrone derivatives TEIJIN LIMITED, MICROBIAL CHEMISTRY RESEARCH FOUNDATION 2003-10-02 US disclosed
US-6589984-B1 Blood cholesterol and triglycerides (TG) themselves are generally insoluble in blood, and they exist as lipoproteins by binding with apolipoproteins. In the body, triglycerides are biosynthesized primarily in the liver from acetyl CoA as TEIJIN LIMITED (JP) 2003-07-08 US disclosed
EP-1063235-A1 BENZOFURYLPYRONE DERIVATIVES TEIJIN LIMITED (JP) 2000-12-27 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030186976-A1 Benzofurylpyrone derivatives PLIN5, ACSL5, PLIN1 SLC26A4 4640/4885MEN1 3634/4885KMT2A 4009/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.