SCHEMBL6594796

SCHEMBL6594796

Cc1c(-c2cc3cc(CC4C(=O)NNC4=O)ccc3o2)oc(=O)c(C)c1O

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 7/20 0.35
CA12 O43570 4/20 0.33
CA2 P00918 4/20 0.33
CA3 P07451 4/20 0.33
CA6 P23280 4/20 0.33
CA7 P43166 4/20 0.33
CA9 Q16790 4/20 0.33
CA14 Q9ULX7 4/20 0.33
CA5B Q9Y2D0 4/20 0.33
CA4 P22748 3/20 0.33
CA5A P35218 2/20 0.32
CA1 P00915 1/20 0.32
ALOX5 P09917 2/20 0.31
PTGES O14684 1/20 0.31
CYP26A1 O43174 1/20 0.31
CYP26B1 Q9NR63 1/20 0.31
KDM4E B2RXH2 1/20 0.31
CHRM2 P08172 1/20 0.31
CHRM4 P08173 1/20 0.31
CHRM5 P08912 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6589632 0.83 MAOA (0.47) FFAR1MAOAMAOB
SCHEMBL6597235 0.80
SCHEMBL6596507 0.80
SCHEMBL6592072 0.79 CYP26A1 (0.31) FFAR1CA12CA2CA3CA6
SCHEMBL6593646 0.78 MAOA (0.33) MAOAMAOB
SCHEMBL6593518 0.77 ESR1 (0.50) CA12CA2CA9CA1KDM4E
SCHEMBL6595237 0.76
SCHEMBL6593243 0.76 POLB (0.43) CA12CA2CA3CA6CA7
SCHEMBL6590228 0.76 ADRA2A (0.37) FFAR1CA12CA2CA3CA6
SCHEMBL6592579 0.75 FLT3 (0.44) CA2KDM4ECHRM2CHRM4CHRM5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1063235-B1 BENZOFURYLPYRONE DERIVATIVES TEIJIN LTD (JP) 2004-05-12 EP disclosed
US-20030186976-A1 Benzofurylpyrone derivatives TEIJIN LIMITED, MICROBIAL CHEMISTRY RESEARCH FOUNDATION 2003-10-02 US disclosed
US-6589984-B1 Blood cholesterol and triglycerides (TG) themselves are generally insoluble in blood, and they exist as lipoproteins by binding with apolipoproteins. In the body, triglycerides are biosynthesized primarily in the liver from acetyl CoA as TEIJIN LIMITED (JP) 2003-07-08 US disclosed
CN-1299359-A Benzofurylpyrone derivatives TEIJIN LTD (JP) 2001-06-13 CN disclosed
EP-1063235-A1 BENZOFURYLPYRONE DERIVATIVES TEIJIN LIMITED (JP) 2000-12-27 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030186976-A1 Benzofurylpyrone derivatives PLIN5, ACSL5, PLIN1 FFAR1 66/4885CA12 4853/4885CA2 3747/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.