Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 4/20 | 0.55 |
| ▸ | CCR2 | P41597 | 15/20 | 0.54 |
| ▸ | EDNRB | P24530 | 2/20 | 0.42 |
| ▸ | EDNRA | P25101 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7086771 | 0.88 | ABCB11 (0.48) | ABCB11CCR2EDNRBEDNRA | |
| SCHEMBL6780182 | 0.81 | ABCB11 (0.66) | ABCB11CCR2 | |
| SCHEMBL6780034 | 0.80 | CCR2 (0.61) | ABCB11CCR2EDNRBEDNRA | |
| SCHEMBL7087364 | 0.75 | ABCB11 (0.52) | ABCB11CCR2 | |
| SCHEMBL6599243 | 0.71 | ABCB11 (1.00) | ABCB11CCR2 | |
| SCHEMBL6595112 | 0.71 | CCR2 (0.59) | ABCB11CCR2 | |
| SCHEMBL7855477 | 0.70 | SMN1; SMN2 (0.52) | ABCB11CCR2 | |
| SCHEMBL7839309 | 0.69 | CCR2 (0.57) | ABCB11CCR2 | |
| SCHEMBL6595450 | 0.69 | CCR2 (0.50) | ABCB11CCR2EDNRBEDNRA | |
| SCHEMBL6785303 | 0.69 | ABCB11 (0.61) | ABCB11CCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1150952-B1 | INDOLE DERIVATIVES AND THEIR USE AS MCP-1 RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2004-10-27 | — | — | EP | disclosed |
| US-6737435-B1 | ANTIINFLAMMATORY AGENTS; MONOCYTE CHEMOATTRACTANT PROTEIN-1 (MCP-1) DISEASES | ASTRAZENECA AB (SE) | 2004-05-18 | — | — | US | disclosed |
| EP-1150952-A1 | INDOLE DERIVATIVES AND THEIR USE AS MCP-1 RECEPTOR ANTAGONISTS | AstraZeneca AB (SE) | 2001-11-07 | — | — | EP | disclosed |
| WO-2000046196-A1 | INDOLE DERIVATIVES AND THEIR USE AS MCP-1 ANTAGONISTS | ASTRAZENECA AB (SE) | 2000-08-10 | — | — | WO | disclosed |