SCHEMBL6596496

SCHEMBL6596496

Cc1c(-c2cc3cc(OCc4cnc(S(=O)(=O)C5CNCCO5)s4)ccc3o2)oc(=O)c(C)c1O

nearest known ligand 0.38

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MKNK1 Q9BUB5 8/20 0.38
S1PR1 P21453 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6590720 0.88 MKNK1 (0.36) MKNK1S1PR1
SCHEMBL6596503 0.80 SMN1; SMN2 (0.38) S1PR1
SCHEMBL27557617 0.79 MKNK1 (0.33) MKNK1
SCHEMBL6594608 0.78 MKNK1 (0.33) MKNK1S1PR1
SCHEMBL27535014 0.77 MKNK1 (0.32) MKNK1
SCHEMBL6593456 0.73 PARP15 (0.41)
SCHEMBL6592699 0.73 MKNK1 (0.37) MKNK1S1PR1
SCHEMBL6595580 0.72 MAOB (0.43) MKNK1S1PR1
SCHEMBL6590245 0.72 ACHE (0.43)
SCHEMBL6591440 0.71 DRD2 (0.42)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1063235-B1 BENZOFURYLPYRONE DERIVATIVES TEIJIN LTD (JP) 2004-05-12 EP disclosed
US-20030186976-A1 Benzofurylpyrone derivatives TEIJIN LIMITED, MICROBIAL CHEMISTRY RESEARCH FOUNDATION 2003-10-02 US disclosed
US-6589984-B1 Blood cholesterol and triglycerides (TG) themselves are generally insoluble in blood, and they exist as lipoproteins by binding with apolipoproteins. In the body, triglycerides are biosynthesized primarily in the liver from acetyl CoA as TEIJIN LIMITED (JP) 2003-07-08 US disclosed
EP-1063235-A1 BENZOFURYLPYRONE DERIVATIVES TEIJIN LIMITED (JP) 2000-12-27 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030186976-A1 Benzofurylpyrone derivatives PLIN5, ACSL5, PLIN1 MKNK1 2780/4885S1PR1 1927/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.