Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | LTA4H | P09960 | 1/20 | 0.32 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL1194586 | 0.90 | ALDH1A1 (0.38) | MAPTALDH1A1MEN1KMT2ALTA4H | |
| SCHEMBL6618821 | 0.89 | MAPT (0.36) | MAPTALDH1A1MEN1KMT2ALTA4H | |
| Hydrochloric Acid SCHEMBL6609904 | 0.83 | POLB (0.34) | MAPTALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL6597741 | 0.82 | LMNA (0.41) | MAPTALDH1A1MEN1KMT2ALMNA | |
| Hydrochloric Acid SCHEMBL1194038 | 0.81 | LMNA (0.42) | MAPTALDH1A1MEN1KMT2ALMNA | |
| Bromide SCHEMBL1194131 | 0.75 | KMT2A (0.35) | MEN1KMT2AHTTRAB9AKDM4E | |
| SCHEMBL6598418 | 0.74 | KMT2A (0.36) | MEN1KMT2AHTTRAB9AKDM4E | |
| Bromide SCHEMBL6598138 | 0.74 | MAPT (0.32) | MAPTALDH1A1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL5364641 | 0.74 | KMT2A (0.35) | MEN1KMT2AHTTRAB9AKDM4E | |
| Bromide SCHEMBL1194391 | 0.73 | SMN1; SMN2 (0.38) | MAPTALDH1A1MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1373263-B1 | HETEROCYCLIC COMPOUNDS FOR AGING-RELATED AND DIABETIC VASCULAR COMPLICATIONS | TORRENT PHARMACEUTICALS LTD (IN) | 2004-10-27 | — | — | EP | claimed |