Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6599921 | 0.80 | LMNA (0.34) | ALDH1A1MEN1KMT2APOLB | |
| SCHEMBL6598296 | 0.79 | SMN1; SMN2 (0.38) | MAPTALDH1A1MEN1KMT2ASMN1; SMN2 | |
| Bromide SCHEMBL1194586 | 0.78 | ALDH1A1 (0.38) | MAPTALDH1A1MEN1KMT2ASMN1; SMN2 | |
| Bromide SCHEMBL1194391 | 0.78 | SMN1; SMN2 (0.38) | MAPTALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL6618821 | 0.77 | MAPT (0.36) | MAPTALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL6597394 | 0.77 | SMN1; SMN2 (0.31) | SMN1; SMN2 | |
| SCHEMBL3689760 | 0.77 | SMN1; SMN2 (0.39) | MAPTALDH1A1MEN1KMT2ASMN1; SMN2 | |
| Bromide SCHEMBL6597813 | 0.74 | MAPT (0.34) | MAPTALDH1A1MEN1KMT2A | |
| Bromide SCHEMBL6599927 | 0.67 | LMNA (0.34) | MAPTALDH1A1MEN1KMT2ASMN1; SMN2 | |
| Bromide SCHEMBL5359071 | 0.67 | EPHX2 (0.41) | MAPTALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1373263-B1 | HETEROCYCLIC COMPOUNDS FOR AGING-RELATED AND DIABETIC VASCULAR COMPLICATIONS | TORRENT PHARMACEUTICALS LTD (IN) | 2004-10-27 | — | — | EP | claimed |