Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6596985 | 0.88 | ABCB11 (0.78) | ABCB11CCR2 | |
| SCHEMBL7087122 | 0.88 | ABCB11 (0.78) | ABCB11CCR2 | |
| SCHEMBL6785298 | 0.86 | ABCB11 (0.76) | ABCB11CCR2 | |
| SCHEMBL6780988 | 0.86 | ABCB11 (0.75) | ABCB11CCR2 | |
| SCHEMBL6303492 | 0.84 | CCR2 (0.74) | ABCB11CCR2 | |
| SCHEMBL6308083 | 0.83 | CCR2 (0.81) | ABCB11CCR2 | |
| SCHEMBL6300727 | 0.82 | CCR2 (1.00) | ABCB11CCR2 | |
| SCHEMBL6993774 | 0.81 | ABCB11 (0.68) | ABCB11CCR2 | |
| SCHEMBL6597658 | 0.81 | ABCB11 (0.67) | ABCB11CCR2 | |
| SCHEMBL7087035 | 0.81 | ABCB11 (0.67) | ABCB11CCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1150952-B1 | INDOLE DERIVATIVES AND THEIR USE AS MCP-1 RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2004-10-27 | — | — | EP | disclosed |
| US-6737435-B1 | ANTIINFLAMMATORY AGENTS; MONOCYTE CHEMOATTRACTANT PROTEIN-1 (MCP-1) DISEASES | ASTRAZENECA AB (SE) | 2004-05-18 | — | — | US | disclosed |
| EP-1150952-A1 | INDOLE DERIVATIVES AND THEIR USE AS MCP-1 RECEPTOR ANTAGONISTS | AstraZeneca AB (SE) | 2001-11-07 | — | — | EP | disclosed |
| WO-2000046196-A1 | INDOLE DERIVATIVES AND THEIR USE AS MCP-1 ANTAGONISTS | ASTRAZENECA AB (SE) | 2000-08-10 | — | — | WO | disclosed |