SCHEMBL6595442

SCHEMBL6595442

COC(=O)c1cc2cc(O)ccc2n1S(=O)(=O)c1ccc(Cl)c(Cl)c1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CCR2 P41597 4/20 0.55
NOD1 Q9Y239 5/20 0.45
NOD2 Q9HC29 4/20 0.45
PTGS2 P35354 4/20 0.44
ABCB11 O95342 1/20 0.43
LGALS8 O00214 1/20 0.40
LGALS3 P17931 1/20 0.40
ACLY P53396 3/20 0.40
L3MBTL1 Q9Y468 1/20 0.39
HDAC3 O15379 1/20 0.38
HDAC4 P56524 1/20 0.38
HDAC1 Q13547 1/20 0.38
HDAC7 Q8WUI4 1/20 0.38
HDAC2 Q92769 1/20 0.38
HDAC10 Q969S8 1/20 0.38
HDAC11 Q96DB2 1/20 0.38
HDAC8 Q9BY41 1/20 0.38
HDAC6 Q9UBN7 1/20 0.38
HDAC9 Q9UKV0 1/20 0.38
HDAC5 Q9UQL6 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6964954 0.90 CCR2 (0.56) CCR2NOD1NOD2PTGS2ACLY
SCHEMBL6963990 0.86 CCR2 (0.74) CCR2NOD1NOD2PTGS2HDAC3
SCHEMBL6596517 0.86 CCR2 (0.73) CCR2NOD1NOD2ABCB11ACLY
SCHEMBL6598140 0.83 CCR2 (0.54) CCR2NOD1NOD2PTGS2HDAC1
SCHEMBL6960221 0.79 CCR2 (0.51) CCR2NOD1NOD2ALDH1A1TSHR
SCHEMBL7516484 0.77 MAPT (0.50) CCR2ALDH1A1TSHR
SCHEMBL6960770 0.77 NOD2 (0.52) CCR2NOD1NOD2PTGS2ACLY
SCHEMBL16486105 0.75 NOD2 (0.58) CCR2NOD1NOD2PTGS2ACLY
SCHEMBL6953098 0.75 CCR2 (0.75) CCR2ABCB11ACLY
SCHEMBL6961229 0.75 PTGS2 (0.51) NOD1NOD2PTGS2ACLYHDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1150952-B1 INDOLE DERIVATIVES AND THEIR USE AS MCP-1 RECEPTOR ANTAGONISTS ASTRAZENECA AB (SE) 2004-10-27 EP disclosed
US-6737435-B1 ANTIINFLAMMATORY AGENTS; MONOCYTE CHEMOATTRACTANT PROTEIN-1 (MCP-1) DISEASES ASTRAZENECA AB (SE) 2004-05-18 US disclosed
EP-1150952-A1 INDOLE DERIVATIVES AND THEIR USE AS MCP-1 RECEPTOR ANTAGONISTS AstraZeneca AB (SE) 2001-11-07 EP disclosed
WO-2000046196-A1 INDOLE DERIVATIVES AND THEIR USE AS MCP-1 ANTAGONISTS ASTRAZENECA AB (SE) 2000-08-10 WO disclosed