Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | TP53 | P04637 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ITGAL | P20701 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1322823 | 0.77 | GSK3B (0.52) | PGRMAPTTP53LMNAGSK3B | |
| SCHEMBL13358162 | 0.70 | PGR (0.48) | PGRMAPTGSK3BKDM4EGAA | |
| SCHEMBL1319928 | 0.70 | PGR (0.48) | PGRMAPTGSK3BKDM4EGAA | |
| SCHEMBL7372759 | 0.69 | GSK3B (0.73) | PGRMAPTTP53LMNAGSK3B | |
| SCHEMBL28010730 | 0.69 | GSK3B (0.59) | MAPTTP53LMNAGSK3BKDM4E | |
| SCHEMBL6744837 | 0.68 | MAPT (0.52) | PGRMAPTTP53LMNAPOLB | |
| SCHEMBL6601335 | 0.68 | PGR (0.54) | PGRITGAL | |
| SCHEMBL7734085 | 0.67 | HSD17B10 (0.46) | MAPTTP53LMNAGSK3BKDM4E | |
| SCHEMBL28010769 | 0.66 | GSK3B (0.59) | PGRMAPTGSK3BKDM4EGAA | |
| SCHEMBL4596500 | 0.65 | RXRA (0.50) | PGRMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1399155-A4 | SMALL MOLECULES USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASE | BOEHRINGER INGELHEIM PHARMA (US) | 2004-12-15 | — | — | EP | disclosed |
| EP-1399155-A2 | SMALL MOLECULES USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASE | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2004-03-24 | — | — | EP | disclosed |
| WO-2001006984-A2 | SMALL MOLECULES USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASE | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2001-02-01 | — | — | WO | disclosed |