Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.65 |
| ▸ | NPC1 | O15118 | 4/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | NT5E | P21589 | 1/20 | 0.41 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.41 |
| ▸ | FEN1 | P39748 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2932069 | 0.84 | RAB9A (0.65) | RAB9ANPC1L3MBTL1KMT2AMEN1 | |
| SCHEMBL15022087 | 0.84 | LMNA (0.48) | RAB9ANPC1L3MBTL1MAPTGSK3B | |
| SCHEMBL29986565 | 0.83 | PLOD2 (0.53) | RAB9ANPC1L3MBTL1MAPTGSK3B | |
| SCHEMBL29130629 | 0.83 | PLOD2 (0.53) | RAB9ANPC1L3MBTL1MAPTGSK3B | |
| SCHEMBL6202998 | 0.79 | RAB9A (1.00) | RAB9ANPC1L3MBTL1MAPTGSK3B | |
| SCHEMBL3252516 | 0.77 | RAB9A (0.60) | RAB9ANPC1L3MBTL1MAPTGSK3B | |
| SCHEMBL10908679 | 0.77 | RAB9A (0.65) | RAB9ANPC1L3MBTL1MAPTGSK3B | |
| SCHEMBL4102938 | 0.76 | L3MBTL1 (0.68) | RAB9ANPC1L3MBTL1MAPTGSK3B | |
| SCHEMBL9993146 | 0.75 | RAB9A (0.67) | RAB9ANPC1L3MBTL1MAPTGSK3B | |
| SCHEMBL28950040 | 0.74 | RAB9A (0.88) | RAB9ANPC1L3MBTL1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040220232-A1 | Novel process for making 5-substituted pyrazoles | PHAMACIA CORPORATION | 2004-11-04 | — | — | US | disclosed |
| US-6750338-B2 | 5-AMINO- AND 5-THIO- SUBSTITUTED; PREPARED FROM A METHYLENEDITHIETANE INTERMEDIATE | PHARMACIA CORPORATION | 2004-06-15 | — | — | US | disclosed |
| EP-1131318-B1 | PROCESS FOR MAKING 5-SUBSTITUTED PYRAZOLES USING DITHIETANES | SEARLE LLC (US) | 2004-03-24 | — | — | EP | disclosed |
| EP-1380584-A1 | Process for making 5-substituted pyrazoles using dithietanes | G.D. SEARLE & CO. (US) | 2004-01-14 | — | — | EP | disclosed |
| US-20030135057-A1 | Novel process for making 5-substituted pyrazoles | PHARMACIA CORPORATION | 2003-07-17 | — | — | US | disclosed |
| US-6482955-B2 | ORGANOMETALLIC REAGENT REACTED WITH AN ACTIVATED CARBOXYLIC ACID TO PRODUCE A KETONE REACTED WITH CARBON DISULFIDE AND DIHALOMETHANE, FURTHER REACTING THE DITHIETANE PRODUCT WITH A SECONDARY AMINE, AND CONDENSING THE THIOAMIDE WITH HYDRAZINE | PHARMACIA CORPORATION | 2002-11-19 | — | — | US | disclosed |
| US-6342608-B1 | REACTING ORGANOMETALLIC REAGENT WITH ACTIVATED CARBOXYLIC ACID TO FORM KETONE, TREATING WITH MIXTURE OF CARBON DISULFIDE AND DIHALOMETHANE TO FORM DITHIETANE, REACTING WITH HYDRAZINE DERIVATIVE TO FORM THIOL-SUBSTITUTED PYRAZOLE, ALKYLATING | G.D. SEARLE & COMPANY | 2002-01-29 | — | — | US | disclosed |
| EP-1131318-A1 | PROCESS FOR MAKING 5-SUBSTITUTED PYRAZOLES USING DITHIETANES | G.D. SEARLE & CO. (US) | 2001-09-12 | — | — | EP | disclosed |
| US-6242612-B1 | Process for making substituted pyrazoles | G. D. SEARLE & CO. | 2001-06-05 | — | — | US | disclosed |
| WO-2001030154-A2 | AGROCHEMICAL COMPOSITIONS CONTAINING PYRAZOLES AND USE THEREOF AS FUNGICIDAL PLANT PROTECTION AGENTS | BASF AKTIENGESELLSCHAFT (DE) | 2001-05-03 | — | — | WO | disclosed |
| US-6143892-A | REACTING AN ORGANOMETALLIC COMPOUND WITH AN ACTIVATED FORM OF CARBOXYLIC ACID TO FORM A KETONE, TREATING KETONE WITH A MIXTURE OF CARBON DISULFIDE AND DIHALOMETHANE, AMIDATING WITH AMINE, CONDENSING THE THIOAMIDE WITH HYDRAZINE OR DERIVATIVE | G. D. SEARLE & CO. (US) | 2000-11-07 | — | — | US | disclosed |
| WO-2000031072-A1 | PROCESS FOR MAKING 5-SUBSTITUTED PYRAZOLES USING DITHIETANES | G.D. SEARLE & CO. (US) | 2000-06-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040220232-A1 | Novel process for making 5-substituted pyrazoles | MAP3K5, MAP4K2, MAPKAPK2 | RAB9A 2827/4885NPC1 4518/4885L3MBTL1 4817/4885 |
| US-20030135057-A1 | Novel process for making 5-substituted pyrazoles | MAP3K5, MAP4K2, MAPKAPK2 | RAB9A 2827/4885NPC1 4518/4885L3MBTL1 4817/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.