Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 4/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 8/20 | 0.40 |
| ▸ | MEN1 | O00255 | 6/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4533236 | 0.75 | SIGMAR1 (0.46) | NPC1RAB9AGAACYP3A4MAPT | |
| SCHEMBL21131268 | 0.75 | NPC1 (0.50) | NPC1RAB9AGAACYP3A4ADRA2A | |
| SCHEMBL21900388 | 0.75 | NPC1 (0.50) | NPC1RAB9AGAACYP3A4ADRA2A | |
| SCHEMBL11883540 | 0.75 | PLAU (0.50) | NPC1RAB9AGAACYP3A4ADRA2A | |
| SCHEMBL11387754 | 0.74 | ACHE (0.52) | NPC1RAB9AGAACYP3A4MAPT | |
| SCHEMBL13599449 | 0.72 | NPC1 (0.51) | NPC1RAB9AGAACYP3A4MAPT | |
| SCHEMBL12589735 | 0.72 | RAB9A (0.50) | NPC1RAB9AGAACYP3A4ADRA2A | |
| SCHEMBL3241980 | 0.71 | NPC1 (0.50) | NPC1RAB9ACYP3A4MAPTMEN1 | |
| SCHEMBL11693231 | 0.71 | NPC1 (0.72) | NPC1RAB9AGAACYP3A4ADRA2A | |
| SCHEMBL1637262 | 0.71 | RAB9A (0.54) | NPC1RAB9AGAACYP3A4ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0966468-B1 | CROWN ETHER-DERIVATISED PERYLENES | CIBA SC HOLDING AG (CH) | 2004-09-22 | — | — | EP | disclosed |
| EP-0867477-B1 | Polycyclic compounds | CIBA SC HOLDING AG (CH) | 2002-05-02 | — | — | EP | disclosed |
| EP-0966468-A1 | CROWN ETHER-DERIVATISED PERYLENES | Ciba SC Holding AG (CH) | 1999-12-29 | — | — | EP | disclosed |
| EP-0867477-A1 | Polycyclic compounds | Ciba SC Holding AG (CH) | 1998-09-30 | — | — | EP | disclosed |
| WO-1998039333-A1 | CROWN ETHER-DERIVATISED PERYLENES | CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) | 1998-09-11 | — | — | WO | disclosed |
| EP-0337945-A1 | Monoketo-pyrrolopyrroles | CIBA-GEIGY AG (CH) | 1989-10-18 | — | — | EP | disclosed |
| EP-0061426-B1 | PROCESS FOR COLOURING HIGHLY MOLECULAR ORGANIC MATERIAL AND POLYCYCLIC PIGMENTS | CIBA-GEIGY AG (CH) | 1985-02-13 | — | — | EP | disclosed |