SCHEMBL6601272

SCHEMBL6601272

CCCOC(=O)c1noc([C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)C2CCN(C(=O)OC(C)(C)C)CC2)n1

nearest known ligand 0.46

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 4/20 0.42
KMT2A Q03164 4/20 0.42
ALDH1A1 P00352 2/20 0.42
YAP1 P46937 3/20 0.41
TACR1 P25103 8/20 0.39
CAPN1 P07384 2/20 0.39
MAPK1 P28482 1/20 0.39
CTSB P07858 1/20 0.38
POLB P06746 1/20 0.38
MAPT P10636 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38
CACNA1B Q00975 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6601359 0.95 MEN1 (0.42) MEN1KMT2AALDH1A1YAP1TACR1
SCHEMBL6601362 0.91 KMT2A (0.42) MEN1KMT2AALDH1A1YAP1TACR1
SCHEMBL6600255 0.91 YAP1 (0.45) MEN1KMT2AALDH1A1YAP1TACR1
SCHEMBL8910446 0.90 MEN1 (0.43) MEN1KMT2AALDH1A1YAP1TACR1
SCHEMBL6601229 0.88 KMT2A (0.45) MEN1KMT2AALDH1A1YAP1TACR1
SCHEMBL2576148 0.82 TACR1 (0.40) TACR1CAPN1
SCHEMBL6602096 0.81 CAPN1 (0.47) TACR1CAPN1CTSB
SCHEMBL6599943 0.81 CTSS (0.48) MEN1KMT2AALDH1A1TACR1CTSB
SCHEMBL6599942 0.81 CTSS (0.48) MEN1KMT2AALDH1A1TACR1CTSB
SCHEMBL6600281 0.80 TACR1 (0.47) TACR1CAPN1CTSB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0805816-B1 COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES NOVO NORDISK AS (DK) 2004-07-28 EP disclosed
US-6350767-B1 GROWTH HORMONE RELEASE STIMULANT NOVO NORDISK A/S (DK) 2002-02-26 US disclosed
US-6013658-A ANIMAL GROWTH REGULATORS NOVO NORDISK A/S (DK) 2000-01-11 US disclosed
WO-1996022997-A1 COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES NOVO NORDISK A/S (DK) 1996-08-01 WO disclosed