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SCHEMBL8910446

SCHEMBL8910446

CNC(=O)c1noc(C(Cc2ccc3ccccc3c2)N(C)C(=O)C(Cc2ccc3ccccc3c2)NC(=O)C2CCN(C(=O)OC(C)(C)C)CC2)n1

nearest known ligand 0.49

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 6/20 0.43
▸ KMT2A Q03164 6/20 0.43
▸ ALDH1A1 P00352 3/20 0.43
▸ TACR1 P25103 7/20 0.43
▸ YAP1 P46937 3/20 0.42
▸ CAPN1 P07384 2/20 0.40
▸ MAPK1 P28482 1/20 0.40
▸ CTSB P07858 1/20 0.40
▸ MAPT P10636 2/20 0.39
▸ POLB P06746 1/20 0.39
▸ NPSR1 Q6W5P4 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6600255 0.93 YAP1 (0.45) MEN1KMT2AALDH1A1TACR1YAP1
SCHEMBL6600281 0.91 TACR1 (0.47) TACR1CAPN1CTSB
SCHEMBL6601359 0.91 MEN1 (0.42) MEN1KMT2AALDH1A1TACR1YAP1
SCHEMBL6601362 0.91 KMT2A (0.42) MEN1KMT2AALDH1A1TACR1YAP1
SCHEMBL6601229 0.90 KMT2A (0.45) MEN1KMT2AALDH1A1TACR1YAP1
SCHEMBL6601272 0.90 MEN1 (0.42) MEN1KMT2AALDH1A1TACR1YAP1
SCHEMBL6602096 0.83 CAPN1 (0.47) TACR1CAPN1CTSB
SCHEMBL6398777 0.81 TACR1 (0.39) TACR1CAPN1
SCHEMBL6601809 0.79 TACR1 (0.43) TACR1
SCHEMBL27477312 0.79 TACR1 (0.43) TACR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0805816-A1 COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES NOVO NORDISK A/S (DK) 1997-11-12 — — EP disclosed
WO-1996022997-A1 COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES NOVO NORDISK A/S (DK) 1996-08-01 — — WO disclosed