SCHEMBL6600281

SCHEMBL6600281

CNC(=O)c1noc(C(Cc2ccc3ccccc3c2)N(C)C(=O)C(Cc2ccc3ccccc3c2)NC(=O)C2CCN(C(=O)O)CC2)n1

nearest known ligand 0.47

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
TACR1 P25103 17/20 0.47
CAPN1 P07384 3/20 0.45
CTSB P07858 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6602096 0.92 CAPN1 (0.47) TACR1CAPN1CTSB
SCHEMBL8910446 0.91 MEN1 (0.43) TACR1CAPN1CTSB
SCHEMBL6600255 0.85 YAP1 (0.45) TACR1CAPN1CTSB
SCHEMBL27477312 0.83 TACR1 (0.43) TACR1
SCHEMBL6601809 0.83 TACR1 (0.43) TACR1
SCHEMBL6601362 0.83 KMT2A (0.42) TACR1CAPN1
SCHEMBL6601359 0.81 MEN1 (0.42) TACR1CAPN1CTSB
SCHEMBL6601229 0.81 KMT2A (0.45) TACR1CAPN1CTSB
SCHEMBL6601272 0.80 MEN1 (0.42) TACR1CAPN1CTSB
SCHEMBL6601553 0.80 MMP9 (0.40) TACR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0805816-B1 COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES NOVO NORDISK AS (DK) 2004-07-28 EP disclosed
US-6350767-B1 GROWTH HORMONE RELEASE STIMULANT NOVO NORDISK A/S (DK) 2002-02-26 US disclosed
US-6013658-A ANIMAL GROWTH REGULATORS NOVO NORDISK A/S (DK) 2000-01-11 US disclosed
EP-0805816-A1 COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES NOVO NORDISK A/S (DK) 1997-11-12 EP disclosed
WO-1996022997-A1 COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES NOVO NORDISK A/S (DK) 1996-08-01 WO disclosed