Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
| ▸ | HTR2B | P41595 | 2/20 | 0.35 |
| ▸ | EDNRA | P25101 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.32 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2508140 | 1.00 | HTR2A (0.35) | HTR2AHTR2CHTR2BEDNRAMEN1 | |
| SCHEMBL316145 | 0.80 | EDNRA (0.35) | EDNRAMAPK1CYP2C19HDAC4HDAC3 | |
| SCHEMBL1119643 | 0.78 | THRB (0.35) | EDNRAMAPK1CYP2C19HDAC4HDAC3 | |
| SCHEMBL746904 | 0.78 | HTR2A (0.38) | HTR2AHTR2CHTR2BCA2RECQL | |
| SCHEMBL1577842 | 0.77 | HTR2A (0.41) | HTR2AHTR2CHTR2BMEN1KMT2A | |
| SCHEMBL3583056 | 0.77 | GRM1 (0.35) | EDNRAMEN1KMT2ALMNAMAPK1 | |
| SCHEMBL2121106 | 0.77 | KDM1A (0.34) | EDNRAMAPK1CYP2C19HDAC4HDAC3 | |
| SCHEMBL4371618 | 0.77 | SLC9A1 (0.36) | EDNRAMAPK1CYP2C19OPRK1POLB | |
| SCHEMBL16290377 | 0.77 | HSD11B1 (0.38) | HTR2AHTR2CHTR2BEDNRAMEN1 | |
| SCHEMBL6709305 | 0.77 | EDNRA (0.34) | EDNRAMAPK1CYP2C19HDAC4HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432693-A2 | MCH RECEPTOR ANTAGONISTS | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-06-30 | — | — | EP | disclosed |
| WO-2003028641-A2 | MCH RECEPTOR ANTAGONISTS | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2003-04-10 | — | — | WO | disclosed |