Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.71 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.71 |
| ▸ | LMNA | P02545 | 1/20 | 0.69 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.69 |
| ▸ | NAMPT | P43490 | 2/20 | 0.66 |
| ▸ | RAB9A | P51151 | 6/20 | 0.65 |
| ▸ | NPC1 | O15118 | 4/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.65 |
| ▸ | TP53 | P04637 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 3/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | GFER | P55789 | 1/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11090153 | 0.86 | NAMPT (0.78) | ROCK2ROCK1LMNAHIF1ANAMPT | |
| SCHEMBL7329481 | 0.86 | ROCK2 (0.73) | ROCK2ROCK1LMNAHIF1ANAMPT | |
| SCHEMBL2105307 | 0.85 | KCNK3 (0.74) | ROCK2ROCK1LMNAHIF1ANAMPT | |
| SCHEMBL3093627 | 0.84 | ROCK2 (0.71) | ROCK2ROCK1LMNAHIF1ANAMPT | |
| SCHEMBL29596226 | 0.84 | ROCK2 (0.71) | ROCK2ROCK1LMNAHIF1ANAMPT | |
| SCHEMBL21391312 | 0.84 | ROCK2 (0.71) | ROCK2ROCK1LMNAHIF1ANAMPT | |
| SCHEMBL5384036 | 0.84 | ROCK2 (0.76) | ROCK2ROCK1LMNAHIF1ANAMPT | |
| SCHEMBL14880208 | 0.83 | ROCK2 (1.00) | ROCK2ROCK1LMNAHIF1ANAMPT | |
| Nicotinanilide SCHEMBL352439 | 0.83 | LMNA (0.83) | ROCK2ROCK1LMNAHIF1ANAMPT | |
| Nicotinanilide SCHEMBL29067673 | 0.83 | LMNA (0.83) | ROCK2ROCK1LMNAHIF1ANAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0922036-B1 | ARYLALKANOYL PYRIDAZINES | MERCK PATENT GMBH (DE) | 2004-03-24 | — | — | EP | disclosed |
| EP-1000035-B1 | SUBSTITUTED 6-PHENYLPHENANTHRIDINES | ALTANA PHARMA AG (DE) | 2002-11-27 | — | — | EP | disclosed |
| US-6479494-B1 | THEY INHIBIT SELECTIVELY PHOSPHODIESTERASE IV, WHICH CAUSES AN INCREASE OF THE INTRACELLULAR CAMP LEVEL AS CAMP INHIBITS BONE DECREASING CELLS AND STIMULATES BONE INCREASING CELLS FOR TREATMENT OF OSTEOPOROSIS | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2002-11-12 | — | — | US | disclosed |
| WO-2000059890-A1 | TETRAHYDROPYRIDAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2000-10-12 | — | — | WO | disclosed |
| US-6121279-A | PHOSPHODIESTERASE INHIBITOR FOR TREATING RESPIRATORY SYSTEM DISORDERS | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 2000-09-19 | — | — | US | disclosed |
| US-6107295-A | Arylalkanoyl pyridazines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-08-22 | — | — | US | disclosed |
| EP-1000035-A1 | SUBSTITUTED 6-PHENYLPHENANTHRIDINES | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 2000-05-17 | — | — | EP | disclosed |
| EP-0922036-A1 | ARYLALKANOYL PYRIDAZINES | MERCK PATENT GmbH (DE) | 1999-06-16 | — | — | EP | disclosed |
| WO-1999005113-A1 | SUBSTITUTED 6-PHENYLPHENANTHRIDINES | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1999-02-04 | — | — | WO | disclosed |
| WO-1998006704-A1 | ARYLALKANOYL PYRIDAZINES | MERCK PATENT GMBH (DE) | 1998-02-19 | — | — | WO | disclosed |