SCHEMBL6602416

SCHEMBL6602416

CC(c1ccc2oc(-c3nc(C(C)(C)C)cs3)cc2c1)n1cc(C#N)c2ccccc21

nearest known ligand 0.33

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
IMPDH2 P12268 1/20 0.31
OGA O60502 1/20 0.31
ALDH1A1 P00352 1/20 0.30
POLB P06746 1/20 0.30
HSD17B10 Q99714 1/20 0.30
XDH P47989 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6599607 0.89 ALDH1A1 (0.31) ALDH1A1POLBHSD17B10
SCHEMBL6599459 0.84 NR3C1 (0.36) ALDH1A1POLBHSD17B10
SCHEMBL7469545 0.81
SCHEMBL6599202 0.77 STAT3 (0.42) ALDH1A1POLBHSD17B10
SCHEMBL6598720 0.73 UGT2B7 (0.34) OGAPOLB
SCHEMBL6598855 0.73 FFAR2 (0.34) OGA
SCHEMBL6599129 0.73 MEN1 (0.33) ALDH1A1HSD17B10XDH
SCHEMBL6598555 0.73 PLK1 (0.42) ALDH1A1POLBHSD17B10
SCHEMBL6600955 0.72 L3MBTL1 (0.34) IMPDH2
SCHEMBL8311107 0.72 CHRM2 (0.41) ALDH1A1POLBHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1170009-B1 Thiazolybenzofuran derivatives and their use as SRS-A and leukotiene antagonists FUJISAWA PHARMACEUTICAL CO (JP) 2004-04-07 EP disclosed
EP-1170009-A2 Thiazolybenzofuran derivatives and their use as SRS-A and leukotiene antagonists FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2002-01-09 EP disclosed
US-5994378-A ANTIALLERGENS; ANTIINFLAMMATORY AGENTS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1999-11-30 US disclosed
EP-0880519-A1 THIAZOLYLBENZOFURAN DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1998-12-02 EP disclosed
WO-1997027190-A1 THIAZOLYLBENZOFURAN DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1997-07-31 WO disclosed