Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.46 |
| ▸ | HPGD | P15428 | 5/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | ERN1 | O75460 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | CTSD | P07339 | 1/20 | 0.39 |
| ▸ | NQO2 | P16083 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.38 |
| ▸ | TUBB | P07437 | 1/20 | 0.38 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6603117 | 0.86 | HPGD (0.56) | ALDH1A1KDM4EHPGDNPSR1CYP2C19 | |
| SCHEMBL6605181 | 0.85 | HPGD (0.56) | ALDH1A1KDM4EHPGDNPSR1CYP2C19 | |
| SCHEMBL6604677 | 0.83 | CTSD (0.48) | ALDH1A1KDM4EHPGDNPSR1CYP2C19 | |
| SCHEMBL4656172 | 0.78 | HPGD (0.43) | ALDH1A1KDM4EHPGDNPSR1CYP2C19 | |
| SCHEMBL9258995 | 0.78 | CA2 (0.48) | ALDH1A1KDM4EHPGDHSD17B10NQO2 | |
| SCHEMBL10560587 | 0.77 | ALDH1A1 (0.47) | ALDH1A1KDM4EHPGDNPSR1CYP2C19 | |
| SCHEMBL29227832 | 0.77 | ALDH1A1 (0.48) | ALDH1A1KDM4EHPGDNPSR1CYP2C19 | |
| SCHEMBL6260463 | 0.76 | KDM4E (0.45) | ALDH1A1KDM4EHPGDNPSR1CYP2C19 | |
| SCHEMBL17509433 | 0.76 | TSHR (0.47) | ALDH1A1KDM4EHSD17B10MEN1KMT2A | |
| SCHEMBL3263989 | 0.75 | ALDH1A1 (0.54) | ALDH1A1KDM4EHPGDNPSR1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1119551-B1 | NAPHTHALENECARBOXAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2004-12-29 | — | — | EP | disclosed |
| EP-1433783-A2 | Naphthalenecarboxamides as tachykinin receptor antagonists | AstraZeneca AB (SE) | 2004-06-30 | — | — | EP | disclosed |
| EP-1119551-A1 | NAPHTHALENECARBOXAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | AstraZeneca AB (SE) | 2001-08-01 | — | — | EP | disclosed |
| WO-2000020389-A1 | NAPHTHALENECARBOXAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2000-04-13 | — | — | WO | disclosed |