Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6603889 | 0.71 | HTR2A (0.68) | HTR2AGRM2DRD2DRD1HTR2C | |
| SCHEMBL6603656 | 0.70 | HTR2A (0.51) | SIGMAR1KCNH2HTR2AGRM2DRD2 | |
| SCHEMBL8279384 | 0.69 | HTR2A (0.62) | KCNH2HTR2AGRM2DRD2ADRA2B | |
| SCHEMBL3046365 | 0.65 | HTR2B (0.74) | SIGMAR1KCNH2HTR2ADRD2ADRA2B | |
| SCHEMBL3046362 | 0.65 | HTR2B (0.74) | SIGMAR1KCNH2HTR2ADRD2ADRA2B | |
| SCHEMBL5206867 | 0.65 | HTR1A (0.83) | — | |
| SCHEMBL17828187 | 0.65 | SIGMAR1 (0.77) | SIGMAR1KCNH2HRH3 | |
| SCHEMBL26807183 | 0.63 | SIGMAR1 (0.52) | SIGMAR1KCNH2DRD2HRH3 | |
| SCHEMBL16056564 | 0.63 | KCNH2 (0.78) | SIGMAR1KCNH2HRH3 | |
| SCHEMBL1991377 | 0.62 | HTR2A (0.62) | KCNH2HTR2AGRM2DRD2ADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1202966-A1 | PIPERIDINE ALCOHOLS | MERCK PATENT GmbH (DE) | 2002-05-08 | — | — | EP | disclosed |
| WO-2001014332-A1 | PIPERIDINE ALCOHOLS | MERCK PATENT GMBH (DE) | 2001-03-01 | — | — | WO | disclosed |