Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 10/20 | 0.68 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.68 |
| ▸ | HTR2C | P28335 | 5/20 | 0.65 |
| ▸ | HTR7 | P34969 | 5/20 | 0.65 |
| ▸ | HTR6 | P50406 | 4/20 | 0.65 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | HTR1A | P08908 | 1/20 | 0.56 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.56 |
| ▸ | DRD2 | P14416 | 1/20 | 0.56 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.56 |
| ▸ | DRD1 | P21728 | 1/20 | 0.56 |
| ▸ | DRD4 | P21917 | 1/20 | 0.56 |
| ▸ | DRD5 | P21918 | 1/20 | 0.56 |
| ▸ | HRH2 | P25021 | 1/20 | 0.56 |
| ▸ | HTR1D | P28221 | 1/20 | 0.56 |
| ▸ | HTR1B | P28222 | 1/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4078621 | 0.81 | HTR2A (1.00) | HTR2AGRM2HTR2CHTR7HTR6 | |
| Hydrochloric Acid SCHEMBL4072830 | 0.80 | HTR2A (0.98) | HTR2AGRM2HTR2CHTR7HTR6 | |
| SCHEMBL8318974 | 0.80 | HTR2A (0.53) | HTR2AGRM2HTR2CHTR7HTR6 | |
| SCHEMBL9368018 | 0.80 | HTR2A (0.72) | HTR2AGRM2HTR2CHTR7HTR6 | |
| SCHEMBL10713583 | 0.79 | WNT3A (0.66) | HTR2AGRM2HTR2CHTR7HTR6 | |
| Hydrochloric Acid SCHEMBL9362999 | 0.79 | HTR2A (0.71) | HTR2AGRM2HTR2CHTR7HTR6 | |
| SCHEMBL6603656 | 0.78 | HTR2A (0.51) | HTR2AGRM2HTR2CDRD2DRD1 | |
| Hydrochloric Acid SCHEMBL10712602 | 0.78 | WNT3A (0.65) | HTR2AGRM2HTR2CHTR7HTR6 | |
| SCHEMBL8550299 | 0.77 | CYP2D6 (0.53) | HTR2AHTR2CHTR7HTR6HSD11B1 | |
| SCHEMBL14318600 | 0.77 | HTR2A (0.81) | HTR2AHTR2CHTR7HTR6HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6756370-B1 | POTENT 5-HT2A RECEPTOR ANTAGONISTS | MERCK PATENT GMBH (DE) | 2004-06-29 | — | — | US | disclosed |
| EP-1202966-B1 | PIPERIDINE ALCOHOLS | MERCK PATENT GMBH (DE) | 2004-06-09 | — | — | EP | disclosed |