Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.40 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | THRB | P10828 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.35 |
| ▸ | CRACR2A | Q9BSW2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6623103 | 0.93 | MAPK14 (0.40) | POLBNAMPTMAPK14MAPTNPC1 | |
| SCHEMBL6617061 | 0.92 | TAOK1 (0.42) | TAOK1TAOK3POLBNAMPTMAPK14 | |
| SCHEMBL6619769 | 0.91 | LMNA (0.40) | MAPK14MAPTNPC1RAB9ALMNA | |
| SCHEMBL6603910 | 0.89 | NAMPT (0.42) | POLBNAMPTMAPK14LMNAKDM4E | |
| SCHEMBL6616663 | 0.88 | RAB9A (0.39) | MAPTTHRBNPC1RAB9ALMNA | |
| SCHEMBL6619186 | 0.88 | MEN1 (0.38) | POLBMAPK14MAPTNPC1RAB9A | |
| SCHEMBL6619665 | 0.87 | P2RY14 (0.41) | POLBNAMPTMAPK14MAPTNPC1 | |
| SCHEMBL6614797 | 0.87 | RAB9A (0.38) | NAMPTMAPTTHRBNPC1RAB9A | |
| SCHEMBL6616766 | 0.87 | ADCY1 (0.41) | MAPTTHRBNPC1RAB9ALMNA | |
| SCHEMBL6621561 | 0.86 | SMN1; SMN2 (0.40) | POLBNAMPTMAPK14MAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |