Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6620487 | 0.93 | CHRNA7 (0.37) | CHRNA7NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL6618430 | 0.92 | ALDH1A1 (0.38) | NPC1RAB9ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL6620091 | 0.89 | KMT2A (0.35) | NPC1RAB9ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL6617950 | 0.89 | LMNA (0.47) | SMN1; SMN2ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL6616778 | 0.88 | JAK2 (0.41) | CHRNA7NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL6620003 | 0.88 | RAB9A (0.39) | CHRNA7NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL6615757 | 0.87 | KDM4C (0.40) | NPC1RAB9ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL6617181 | 0.87 | KDM4E (0.37) | NPC1RAB9ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL6617649 | 0.85 | RAB9A (0.43) | RAB9AKDM4ELMNAACKR3 | |
| SCHEMBL6615568 | 0.85 | MAPT (0.43) | NPC1RAB9ASMN1; SMN2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |