Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CRACR2A | Q9BSW2 | 4/20 | 0.41 |
| ▸ | NAMPT | P43490 | 2/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 4/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.39 |
| ▸ | KDM6B | O15054 | 1/20 | 0.39 |
| ▸ | KDM5A | P29375 | 1/20 | 0.39 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.39 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.39 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.39 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6604168 | 0.92 | CRACR2A (0.42) | CRACR2ANAMPTKDM4CKDM6BKDM5A | |
| SCHEMBL6618475 | 0.90 | RAB9A (0.42) | RAB9ANAMPTKDM4CKDM6BKDM5A | |
| SCHEMBL6617307 | 0.89 | CRACR2A (0.44) | CRACR2ANAMPTKDM4CKDM6BKDM5A | |
| SCHEMBL6615568 | 0.87 | MAPT (0.43) | RAB9AKDM4ELMNA | |
| SCHEMBL6608110 | 0.87 | CRACR2A (0.44) | CRACR2ANAMPTACKR3KDM4ELMNA | |
| SCHEMBL6616778 | 0.87 | JAK2 (0.41) | RAB9AKDM4ELMNA | |
| SCHEMBL6620553 | 0.87 | RAB9A (0.42) | RAB9AKDM4CACKR3KDM4ELMNA | |
| SCHEMBL6603917 | 0.85 | CHRNA7 (0.36) | RAB9AACKR3KDM4ELMNA | |
| SCHEMBL6677022 | 0.85 | NAMPT (0.45) | RAB9ACRACR2ANAMPTROCK2ACKR3 | |
| SCHEMBL6661397 | 0.85 | CRACR2A (0.45) | CRACR2AKDM4CACKR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |